250726-39-7

Basic information

• Product Name: ETHYL 2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE
• Synonyms: ETHYL 2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE;2-(Methylthio)-4-pyrimidinecarboxylic acid ethyl ester;4-PyriMidinecarboxylic acid, 2-(Methylthio)-, ethyl ester
• CAS NO: 250726-39-7
• Molecular Formula: C8H10N2O2S
• Molecular Weight: 198.2422
• Mol File: 250726-39-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 313.5 °C at 760 mmHg
• Flash Point: 143.4 °C
• Appearance: /
• Density: 1.24
• Vapor Pressure: 0.000495mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.43±0.20(Predicted)
• CAS DataBase Reference: ETHYL 2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE(250726-39-7)
• EPA Substance Registry System: ETHYL 2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE(250726-39-7)

Safety Data

• Hazardous Substances Data: 250726-39-7(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(methylthio)pyrimidine-4-carboxylate is a chemical compound with the molecular formula C8H10N2O2S. Ethyl 2-(methylthio)pyrimidine-4-carboxylate belongs to the class of organic compounds known as pyrimidines and pyrimidine derivatives. Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms in a six-member ring. This specific compound is relatively stable, but like all organic matter, it can react with oxidizing agents. Its precise properties would depend on its purity and specific use. Most commonly, it's used for research in a lab setting. It is less commonly used in the manufacturing of more complex chemical products.

InChI:InChI=1/C8H10N2O2S/c1-3-12-7(11)6-4-5-9-8(10-6)13-2/h4-5H,3H2,1-2H3

Upstream product

• 623-49-4 ethyl cyanoformate 
• 1122-74-3 4-iodo-2-(methylthio)pyrimidine 
• 67751-14-8 ethyl 4-(dimethylamino)-2-oxo-3-butenoate 
• 867-44-7 S-Methylisothiourea sulfate 
• 76240-19-2 4-ethoxy-2-oxobut-3-enoic acid ethyl ester 
• 53114-57-1 S-methylisothiourea hydrochloride 

Downstream Products

• 1126-44-9 2-methylsulfanylpyrimidine-4-carboxylic acid 

Relevant articles and documents

Antiparasitic activities of novel pyrimidine N-acylhydrazone hybrids

In this article, a series of 29 new pyrimidine N-acylhydrazone hybrids were synthesized and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi protozoa that cause the neglected diseases cutaneous leishmaniasis and Chagas disease, respectively. Eight of the target compounds showed significant antiprotozoal activities with IC50 values in 4.3–33.6 μM range. The more active compound 4f exhibited selectivity index greater than 15 and drug-like properties based on Lipinski's rule.

Process for producing 2-substituted thiopyrimidine-4-carboxylate

There is disclosed a process for producing a 2-substituted thiopyrimidine-4-carboxylate represented by the formula (3): wherein R2 represents a substituted or unsubstituted hydrocarbon group and R3 represents a hydrocarbon group, which comprises reacting an α-keto ester compound represented by the formula (1): R1OCH═CHCOCO2R2??(1) wherein R1 represents a substituted or unsubstituted hydrocarbon group, and R2 has the same meaning as defined above, with an isothiourea compound represented by the formula (2): wherein R3 has the same meaning as defined above.