25137-01-3Relevant articles and documents
Ring-chain tautomerism in 2,2-bis(2-thienyl)-tetrahydrofurans: Preparation of [butene-2H5]-tiagabine
Herberta, John M.,Mathersa, Trevor W.
, p. 598 - 600 (2010)
A concise preparation of [butene-2H5]-tiagabine hydrochloride starting from [2H6]-γ-butyrolactone is described. It was necessary to ring-open the labeled γ-butyrolactone precursor before the addition of 2-thienyllithium to avoid cyclisation of the intermediate to a 2,2-bis(2-thienyl)tetrahydrofuran. Copyright
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure-activity relationships
Fish, Paul V.,Andrews, Mark D.,Jonathan Fray,Stobie, Alan,Wakenhut, Florian,Whitlock, Gavin A.
scheme or table, p. 2829 - 2834 (2010/03/03)
Single enantiomer [(aryloxy)(pyridinyl)methyl]piperidine and pyrrolidine derivatives 5-9 are inhibitors of monoamine reuptake. Structure-activity relationships established that monoamine reuptake inhibition are functions of amine, pyridine isomer, aryloxy ring substitution and stereochemistry. Consequently, selective NRIs, selective SRIs, dual SNRIs and triple SNDRIs were all identified. Dual SNRIs 5l-a and 9c were evaluated in additional pharmacology and pharmacokinetic studies as representative examples from this series.
Enantioselective addition of diethylzinc to aldehydes catalyzed by ethyl nipecotate- derived new chiral ligand
Lee, So Ha,Im, Dai Sig,Cheong, Chan Seong,Chung, Bong Young
, p. 1913 - 1919 (2007/10/03)
(R)-(-)-Diphenyl-(N-methylpiperidin-3-yl)methanol (3) derived from (±)- ethyl nipecotate catalyzed the enantioselective addition of diethylzinc to various aldehydes in good to moderate optical yield (40% - 81%).
