252019-65-1

Basic information

• Product Name: N,N-DIBOC-2-CHLORO-4-NITROANILINE
• Synonyms: N,N-DIBOC-2-CHLORO-4-NITROANILINE
• CAS NO: 252019-65-1
• Molecular Formula: C₁₆H₂₁ClN₂O₆
• Molecular Weight: 372.8
• Mol File: 252019-65-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 442.1°C at 760 mmHg
• Flash Point: 221.2°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 5.15E-08mmHg at 25°C
• Refractive Index: 1.55
• PKA: -6.04±0.50(Predicted)
• CAS DataBase Reference: N,N-DIBOC-2-CHLORO-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIBOC-2-CHLORO-4-NITROANILINE(252019-65-1)
• EPA Substance Registry System: N,N-DIBOC-2-CHLORO-4-NITROANILINE(252019-65-1)

Safety Data

• Hazardous Substances Data: 252019-65-1(Hazardous Substances Data)

Usage

General Description

N,N-DIBOC-2-CHLORO-4-NITROANILINE is a chemical compound that belongs to the family of chloroanilines, which are widely used in the production of dyes, pigments, and pharmaceuticals. It is a yellow crystalline solid with a molecular formula of C16H18ClNO5 and a molecular weight of 335.77 g/mol. N,N-DIBOC-2-CHLORO-4-NITROANILINE is often utilized in organic synthesis as a versatile building block due to its reactivity and ability to undergo various chemical reactions, such as nitration, acylation, and reduction. Additionally, N,N-DIBOC-2-CHLORO-4-NITROANILINE is also commonly employed as a reagent in the production of pharmaceutical intermediates and agrochemicals. However, it is important to handle this compound with care as it is toxic and may pose health hazards if not handled properly.

InChI:InChI=1/C16H21ClN2O6/c1-15(2,3)24-13(20)18(14(21)25-16(4,5)6)12-8-7-10(19(22)23)9-11(12)17/h7-9H,1-6H3

Upstream product

• 1122-58-3 dmap 
• 24424-99-5 di-tert-butyl dicarbonate 
• 121-87-9 2-Chloro-4-nitroaniline 

Downstream Products

• 1266338-26-4 N-(3-chloro-4-(5-phenylfuran-2-carboxamido)phenyl)picolinamide 
• 1266338-24-2 N-(3-chloro-4-(thiophene-2-carboxamido)phenyl)picolinamide 
• 1266338-23-1 N-(2-chloro-4-(picolinamido)phenyl)thiazole-2-carboxamide 
• 1266338-22-0 N-(2-chloro-4-(picolinamido)phenyl)thiazole-5-carboxamide 
• 1266338-21-9 N-(3-chloro-4-(2-methoxybenzamido)phenyl)picolinamide 
• 1266338-19-5 N-(3-chloro-4-(2,4-difluorobenzamido)phenyl)picolinamide 
• 1266338-18-4 N-(3-chloro-4-(2-fluorobenzamido)phenyl)picolinamide 
• 1266338-17-3 N-(3-chloro-4-isobutyramidophenyl)picolinamide 
• 1266338-16-2 N-(3-chloro-4-(2-chloro-4-fluorobenzamido)phenyl)picolinamide 
• 1266338-15-1 N-(4-benzamido-3-chlorophenyl)picolinamide 
• 1266338-14-0 N-(3-chloro-4-(cyclohexanecarboxamido)phenyl)picolinamide 
• 1266338-13-9 N-(3-chloro-4-(2-methylbenzamido)phenyl)picolinamide 
• 1308655-78-8 N-(3-chloro-4-aminophenyl)-2-picolinamide 
• 848134-35-0 C₃₃H₃₉ClN₆O₆ 

Relevant articles and documents

MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Herein we report the discovery, synthesis, and evaluation of a series of N-(4-acetamido)-phenylpicolinamides as positive allosteric modulators of mGlu4. Compounds from the series show submicromolar potency at both human and rat mGlu4. In addition, pharmacokinetic studies utilizing subcutaneous dosing demonstrated good brain exposure in rats.

Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4

There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4). However, most of the data ge