252049-12-0

Basic information

• Product Name: FMOC-D-LYS(NICOTINOYL)-OH
• Synonyms: Nα-Fmoc-Nε-nicotinoyl-D-lysine;N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-(3-pyridinylcarbonyl)-D-lysine;Fmoc-Nε-nicotinoyl-D-lysine;Nα-Fmoc-Nε-nicotinoyl-D-lysine≥ 98% (HPLC);N-ALPHA-FMOC-N-EPSILON-NICOTINYL-D-LYSINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-NICOTINYL-D-LYSINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-NICOTINOYL-D-LYSINE;FMOC-D-LYS(NIC)-OH
• CAS NO: 252049-12-0
• Molecular Formula: C27H27N3O5
• Molecular Weight: 473.52
• Product Categories: Amino Acids
• Mol File: 252049-12-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: FMOC-D-LYS(NICOTINOYL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-LYS(NICOTINOYL)-OH(252049-12-0)
• EPA Substance Registry System: FMOC-D-LYS(NICOTINOYL)-OH(252049-12-0)

Safety Data

• Hazardous Substances Data: 252049-12-0(Hazardous Substances Data)

Usage

General Description

FMOC-D-LYS(NICOTINOYL)-OH is a chemical compound used in biochemical research, specifically in peptide synthesis. The "FMOC" part of the name refers to the 9-fluorenylmethoxycarbonyl group, which works as a protecting group for the synthesis of peptides. The "D-LYS" refers to the D-lysine amino acid. The "NICOTINOYL" denotes the presence of a nicotinoyl group, which is derived from nicotinic acid or niacin, a form of vitamin B3. Lastly, "OH" indicates the presence of a hydroxyl group. The exact function and properties of this specific compound would depend on its use within the context of a scientific research or experiment.

Upstream product

• 1245942-38-4 (S)-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(nicotinamido)hexanoate 

Relevant articles and documents

Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2

Sirtuins catalyze the NAD+ dependent deacetylation of N ε-acetyl lysine residues to nicotinamide, O′-acetyl-ADP- ribose (OAADPR) and Nε-deacetylated lysine. Here, an easy-to-synthesize Ac-Ala-Lys-Ala sequence has been used as a probe for the screening of novel Nε-modified lysine containing inhibitors against SIRT1 and SIRT2. Nε-Selenoacetyl and N ε-isothiovaleryl were the most potent moieties found in this study, comparable to the widely studied Nε-thioacetyl group. The Nε-3,3-dimethylacryl and Nε-isovaleryl moieties gave significant inhibition in comparison to the Nε-acetyl group present in the substrates. In addition, the studied Nε- alkanoyl, Nε-α,β-unsaturated carbonyl and N ε-aroyl moieties showed that the acetyl binding pocket can accept rather large groups, but is sensitive to even small changes in electronic and steric properties of the Nε-modification. These results are applicable for further screening of Nε-acetyl analogues.