25219-53-8

Basic information

• Product Name: 2-(2-pyrrolidinylidene)-Acetic acid ethyl ester
• Synonyms: 2-(2-pyrrolidinylidene)-Acetic acid ethyl ester
• CAS NO: 25219-53-8
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19432
• Mol File: 25219-53-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-pyrrolidinylidene)-Acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-pyrrolidinylidene)-Acetic acid ethyl ester(25219-53-8)
• EPA Substance Registry System: 2-(2-pyrrolidinylidene)-Acetic acid ethyl ester(25219-53-8)

Safety Data

• Hazardous Substances Data: 25219-53-8(Hazardous Substances Data)

Usage

Usage

Precursor in the synthesis of pharmaceuticals and organic compounds

Physical properties

Colorless liquid, characteristic odor, soluble in organic solvents

Applications

Pharmaceutical industry (synthesis of various drugs), chemical research (reagent)

Safety precautions

Potential hazards, should be handled with care, stored and used according to proper safety protocols.

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 105-36-2 ethyl bromoacetate 
• 58322-48-8 (E)-ethyl 3-oxo-2-(pyrrolidin-2-ylidene)butanoate 

Downstream Products

• 1257633-87-6 ethyl 3-phenyl-3-(2-phenylhydrazono)-2-(pyrrolidin-2-yliden)propanoate 
• 1204306-03-5 ethyl 2-{1-(4-chlorophenyl)-3-(4-nitrophenyl)-5,6,7,7a-tetrahydropyrrolo[1,2-d][1,2,4]triazol-7a-yl}acetate 
• 1204306-02-4 ethyl 3-(2-(4-chlorophenyl)hydrazono)-3-(4-nitrophenyl)-2-(pyrrolidin-2-yliden)propanoate 
• 1257633-88-7 ethyl 3-(4-bromophenyl)-3-(2-(4-chlorophenyl)hydrazono)-2-(pyrrolidin-2-yliden)propanoate 
• 1184722-63-1 ethyl 2-(3,4-dihydro-2H-pyrrol-5-yl)-2-(hydroxyimino)acetate 

Relevant articles and documents

Tandem transformations of nitriles into N-heterocyclic compounds by electrophilic trapping of Blaise reaction intermediates

Tandem transformations of nitriles into various N-heterocycles have been accomplished through the reaction of electrophiles with Blaise reaction intermediates formed in situ. The reaction of the Blaise reaction intermediates with propiolates gives 2-pyridones through consecutive C- and N-nucleophilic reactions. The tandem reactions of the Blaise reaction intermediate with 1,3-enynes proceed through C-nucleophilic addition followed by an electrocyclization-aromatization cascade to give pyridines. Exocyclic enamino esters can be prepared by transformations of ω-chloroalkyl nitriles through chemoselective intramolecular alkylation of the Blaise reaction intermediate. Palladium-catalyzed intramolecular arylations or copper-catalyzed intermolecular cross-coupling reactions of the Blaise reaction intermediate give a range of indole derivatives. Combinations of tandem alkylations and palladium-catalyzed couplings of the Blaise reaction intermediates of ω-chloroalkyl nitriles give N-fused indoles. Georg Thieme Verlag Stuttgart · New York.

Anti-mycobacterial 7-hydroxy-2,3-dihydro-1H-indolizin-5-ones

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