25234-25-7Relevant articles and documents
Solid-phase synthesis of isotope-labeled 2-propyloctanoic acid, a therapeutic agent for stroke and Alzheimer's disease
Ho, Jonathan Z.,Tang, Cheng,Braun, Matthew P.
, p. 496 - 497 (2007)
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Mild, single-pot hydrocarboxylation of linear C5-C9 alkanes into branched monocarboxylic C6-C10 acids in copper-catalyzed aqueous systems
Kirillova, Marina V.,Kirillov, Alexander M.,Pombeiro, Armando J.L.
experimental part, p. 106 - 113 (2012/04/04)
A single-pot method has been developed for the hydrocarboxylation of the liquid C5-C9 alkanes (n-pentane, n-hexane, n-heptane, n-octane, n-nonane and 3-methylhexane) into the branched monocarboxylic C 6-C10 acids bearing one more carbon atom. This method is characterized by a direct, selective and low-temperature (60 °C) hydrocarboxylation reaction of the alkane with carbon monoxide, water (which acts as a reagent besides being a solvent component) and potassium peroxodisulfate, in H2O/MeCN medium. The hydrocarboxylations are markedly enhanced in the presence of a tetracopper(II) triethanolaminate complex as a homogeneous catalyst precursor. Total yields (based on alkane) of carboxylic acids up to 46% (with 97-99% overall selectivity) have been achieved, which are remarkable in the field of alkane functionalization under mild conditions, especially for a C-C bond formation reaction in aqueous acid-solvent-free medium. The regio- and bond selectivity parameters have been determined and a free radical mechanism has been proposed.
EFFECT OF SMALL AMOUNTS OF PPh3 AND SnCl2 IN THE CARBONYLATION OF 1-NONENE CATALYZED BY PdCl2
Karpyuk, A. D.,Kolosova, N. D.,Terekhova, M. I.,Petrov, E. S.,Beletskaya, I. P.
, p. 266 - 268 (2007/10/02)
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