252342-46-4Relevant articles and documents
Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol
Paterson, Ian,Naylor, Guy J.,Gardner, Nicola M.,Guzman, Esther,Wright, Amy E.
scheme or table, p. 459 - 473 (2011/10/12)
The design, synthesis, and biological evaluation of a series of hybrids and analogues of the microtubule-stabilizing anticancer agents dictyostatin, discodermolide, and taxol is described. A 22-membered macrolide scaffold was prepared by adapting earlier
Development of a third-generation total synthesis of (+)-discodermolide: An expedient Still-Gennari-type fragment coupling utilizing an advanced β-ketophosphonate
Paterson, Ian,Lyothier, Isabelle
, p. 5494 - 5507 (2008/04/18)
A novel total synthesis of the complex polyketide discodermolide, a promising anticancer agent of marine sponge origin, has been completed in 11.1% overall yield over 21 linear steps. This third-generation approach features an unprecedented Still-Gennari-
Gram-scale synthesis of (+)-discodermolide.
Smith 3rd.,Kaufman,Beauchamp,LaMarche,Arimoto
, p. 1823 - 1826 (2008/02/11)
[formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.