252378-68-0 Usage
Description
Boc-Aminooxy-PEG2-Azide is a versatile click chemistry crosslinker molecule that facilitates PEGylation through the use of click chemistry. The molecule features a protected aminooxy group that can be deprotected under acidic conditions, allowing it to react with aldehyde or ketone groups to form a stable oxime linkage. This unique structure makes it a valuable tool in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
Boc-Aminooxy-PEG2-Azide is used as a crosslinking agent for the development of drug conjugates and prodrugs. Its ability to form stable oxime linkages with aldehyde or ketone groups allows for the creation of targeted drug delivery systems, improving the therapeutic efficacy and reducing side effects of various medications.
Used in Bioconjugation:
In the field of bioconjugation, Boc-Aminooxy-PEG2-Azide serves as a key component in the formation of stable bioconjugates. Its reactivity with aldehyde or ketone groups enables the attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces, facilitating the development of novel diagnostic and therapeutic tools.
Used in Materials Science:
Boc-Aminooxy-PEG2-Azide is utilized as a crosslinking agent in the synthesis of functional polymers and materials. Its compatibility with a wide range of chemical groups allows for the creation of materials with tailored properties, such as self-healing polymers, stimuli-responsive materials, or biocompatible coatings for medical devices.
Used in Chemical Synthesis:
In chemical synthesis, Boc-Aminooxy-PEG2-Azide acts as a versatile building block for the construction of complex organic molecules. Its ability to form stable oxime linkages can be employed in the synthesis of natural products, pharmaceuticals, or other specialty chemicals, contributing to the advancement of organic chemistry and its applications.
Check Digit Verification of cas no
The CAS Registry Mumber 252378-68-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,2,3,7 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 252378-68:
(8*2)+(7*5)+(6*2)+(5*3)+(4*7)+(3*8)+(2*6)+(1*8)=150
150 % 10 = 0
So 252378-68-0 is a valid CAS Registry Number.
252378-68-0Relevant articles and documents
COMPOSITIONS AND METHODS RELATED TO ANTI-CD19 ANTIBODY DRUG CONJUGATES
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Page/Page column 33; 36; 37, (2017/04/11)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD 19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO
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Page/Page column 60; 61, (2017/06/27)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
COMPOUNDS COMPRISING SELF-IMMOLATIVE GROUP
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Paragraph 0242; 0243, (2016/08/03)
Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
