252873-00-0

Basic information

• Product Name: (3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol
• Synonyms: (3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol;BIS THF Nitro Derivative 3
• CAS NO: 252873-00-0
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• Product Categories: Chiral Reagents;Heterocycles;Impurities;Intermediates;Chiral Reagents, Heterocycles, Impurities, Intermediates
• Mol File: 252873-00-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 251.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.275±0.06 g/cm3(Predicted)
• PKA: 14.07±0.20(Predicted)
• CAS DataBase Reference: (3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol(252873-00-0)
• EPA Substance Registry System: (3R,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-ol(252873-00-0)

Safety Data

• Hazardous Substances Data: 252873-00-0(Hazardous Substances Data)

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 23147-58-2 glycolaldehyde dimer 

Downstream Products

• 725264-64-2 (3S,3AR,6AS)-hexahydrofuro[2,3-b]furan-3-yl benzoate 
• 206361-99-1 darunavir 

Relevant articles and documents

Efficient synthesis of 3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol from glycolaldehyde

A one-step diastereoselective (up to 98:2) synthesis of the bis-furan alcohol of Darunavir and other HIV drug candidates has been achieved utilizing the novel cyclizatlon of glycolaldehyde and 2,3-dihydrofuran. The cycloaddition was catalyzed by a variety of catalysts including those formed from tin(II) triflate and common chiral ligands such as BINAP and Evans's box ligands. An efficient and unique enzymatic process enhanced the enantiomeric purity to provide the target in optically pure form.