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2529-45-5

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2529-45-5 Usage

Uses

Flugestone 17-acetate is a synthetic progesterone, used to induce oestrus synchronisation in goats and sheep.

Check Digit Verification of cas no

The CAS Registry Mumber 2529-45-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,2 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2529-45:
(6*2)+(5*5)+(4*2)+(3*9)+(2*4)+(1*5)=85
85 % 10 = 5
So 2529-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H31FO5/c1-13(25)22(29-14(2)26)10-8-17-18-6-5-15-11-16(27)7-9-20(15,3)23(18,24)19(28)12-21(17,22)4/h11,17-19,28H,5-10,12H2,1-4H3/t17-,18-,19-,20-,21-,22-,23-/m0/s1

2529-45-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Flugestone 17-Acetate

1.2 Other means of identification

Product number -
Other names [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2529-45-5 SDS

2529-45-5Synthetic route

9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione
337-03-1

9-fluoro-11β,17-dihydroxy-pregn-4-ene-3,20-dione

acetyl chloride
75-36-5

acetyl chloride

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
With triethylamine In chloroform at 10 - 65℃; Temperature;97.6%
C23H30O5

C23H30O5

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
With hydrogen fluoride In N,N-dimethyl-formamide at -7 - -5℃; for 1h; Temperature;90%
17-acetoxy-9,11β-epoxy-9β-pregn-4-ene-3,20-dione
24320-12-5, 94425-51-1

17-acetoxy-9,11β-epoxy-9β-pregn-4-ene-3,20-dione

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
With hydrogen fluoride
17-acetoxy-9-bromo-11β-hydroxy-pregn-4-ene-3,20-dione
24320-15-8

17-acetoxy-9-bromo-11β-hydroxy-pregn-4-ene-3,20-dione

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; water containing tetrahydrofuran
2: HF
View Scheme
pregna-4,9(11)-diene-3,20-dione-17-hydroxy-21-methyl
34184-82-2

pregna-4,9(11)-diene-3,20-dione-17-hydroxy-21-methyl

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / 1.25 h / 40 - 50 °C / Inert atmosphere
2: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / acetone; water / 2.17 h / 0 - 60 °C / Inert atmosphere
3: potassium carbonate / acetone; water / 5.5 h / 0 - 3 °C / Inert atmosphere
4: hydrogen fluoride / N,N-dimethyl-formamide / 1 h / -7 - -5 °C
View Scheme
17-acetoxy-pregna-4,9(11)-diene-3,20-dione
5106-48-9

17-acetoxy-pregna-4,9(11)-diene-3,20-dione

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / acetone; water / 2.17 h / 0 - 60 °C / Inert atmosphere
2: potassium carbonate / acetone; water / 5.5 h / 0 - 3 °C / Inert atmosphere
3: hydrogen fluoride / N,N-dimethyl-formamide / 1 h / -7 - -5 °C
View Scheme
Fludrocortisone
127-31-1

Fludrocortisone

fluorogestone acetate
2529-45-5

fluorogestone acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; p-toluenesulfonyl chloride / dichloromethane; toluene / 40 - 45 °C
2: sodium iodide; sodium dithionite / ethanol; water / 80 - 85 °C
3: triethylamine / chloroform / 10 - 65 °C
View Scheme
fluorogestone acetate
2529-45-5

fluorogestone acetate

17-acetoxy-9-fluoro-pregn-4-ene-3,11,20-trione
377-26-4

17-acetoxy-9-fluoro-pregn-4-ene-3,11,20-trione

Conditions
ConditionsYield
With pyridine; chromium(VI) oxide

2529-45-5Relevant articles and documents

Preparation method of flurogestone acetate

-

Paragraph 0013; 0014; 0015, (2017/12/13)

The invention discloses a preparation method of flurogestone acetate. The preparation method comprises the following steps: using 9a-cortisone bifluoride as a raw material, dissolving 9a-cortisone bifluoride into an organic solvent, and reacting with acyl chloride under the existence of an acid-binding agent to obtain a 9a-cortisone bifluoride-21-O-ester; then reacting the ester with sodium iodide and a sulfur-containing reducing agent in the organic solvent for deesterification, and synthesizing flugestone; and finally reacting the flugestone with acetylchloride or acetic anhydride in the organic solvent, and synthesizing flurogestone acetate. According to the preparation method, 9a-cortisone bifluoride is used as the raw material, flurogestone acetate is synthesized through three-step reaction of 21-site esterification, then reduction and de-esterification and finally 17-site ethyl esterification, and compared with a traditional synthetic method for using a mold removal object acquired through diosgenin processing as a raw material, the preparation method has the advantages such as wide raw material source, short synthetic route, simple, convenient and environmentally-friendly process, few invested equipment and high product yield, and the production cost in the method is reduced by 25% to 30% as compared with a traditional method; and a solvent used in the production can be recycled and circularly used, and is easy for industrial production.

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