25343-52-6Relevant articles and documents
Nitric oxide donor micromolecule, and preparation method and application thereof
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Paragraph 0033-0037, (2019/11/28)
The invention discloses a donor micromolecule, and a preparation method and application thereof. The donor micromolecule contains a nitroreductase trigger group and a novel nitric oxide donor (N-hydroxyguanidine), and has the advantages of simple synthesis process and efficient and rapid application. The donor micromolecule can release high-concentration nitric oxide under trigger of over-expressed nitroreductase in mitochondria of tumor cells to kill cancer cells. The nitric oxide donor introduced into the small molecule is applied to biological research for the first time, and the inventionprovides a new tool for developing a new nitric oxide release system and inhibiting activity of tumor cells.
Efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles with aminoiminomethanesulfonic acid derivatives
Mohanazadeh, Farajollah,Nami, Navabe,Hosseini, Samine Sadat
experimental part, p. 1055 - 1058 (2012/01/04)
A highly efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles from aminoiminomethanesulfonic acid derivatives is described. The method is simple and practical, generating imidazoline and benzimidazoline derivatives in excellent isolated yields.
A Convenient Synthesis of Guanidines from Thioureas
Maryanoff, Cynthia A.,Stanzione, Robin C.,Plampin, James N.,Mills, John E.
, p. 1882 - 1884 (2007/10/02)
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