253662-82-7

Basic information

• Product Name: 1,3-Dioxane-4-carboxaldehyde, 2-(4-methoxyphenyl)-5,5-dimethyl-, (2R,4R)-
• CAS NO: 253662-82-7
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol File: 253662-82-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxane-4-carboxaldehyde, 2-(4-methoxyphenyl)-5,5-dimethyl-, (2R,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4-carboxaldehyde, 2-(4-methoxyphenyl)-5,5-dimethyl-, (2R,4R)-(253662-82-7)
• EPA Substance Registry System: 1,3-Dioxane-4-carboxaldehyde, 2-(4-methoxyphenyl)-5,5-dimethyl-, (2R,4R)-(253662-82-7)

Safety Data

• Hazardous Substances Data: 253662-82-7(Hazardous Substances Data)

Upstream product

• 599-04-2 (R)-Pantolacton 
• 333956-92-6 (2R,4R)-4-hydroxymethyl-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane 
• 60856-63-5 (2R)-(-)-3,3-dimethylbutane-1,2,4-triol 

Downstream Products

• 1252660-28-8 C₂₆H₄₂O₅Si 
• 1252660-27-7 C₂₃H₃₆O₄Si 
• 1252660-34-6 C₁₇H₂₂O₄ 
• 1252660-35-7 1-(2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)but-2-yn-1-ol 
• 1217182-52-9 1-(2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl)but-2-yn-1-ol 
• 1007389-20-9 1-[(2R,4R)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxan-4-yl]-2-methylallyl acetate 
• 1007389-36-7 C₁₇H₂₄O₄ 
• 253663-02-4 (2R,3R,5R,6S,7S*,8R)-2,6-Dibenzyloxy-3-(tert-butyldimethylsiloxy)-7-hydroxy-5-(p-methoxybenzyloxy)-4,4,8-trimethylcyclooctanone 
• 333956-95-9 (4R,5R,7R,8S)-4,8-bis(benzyloxy)-5,9-bis(t-butyldimethylsiloxy)-2,2-dichloro-7-(4-methoxybenzyloxy)-6,6-dimethylnonan-3-ol 
• 198711-92-1 (2R,3R,5R,6S,7S,8R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsiloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-4,4,8-trimethylcyclooctanone 
• 299939-00-7 (2R,3R,5R,6S,7R,8R)-2,6-bis(benzyloxy)-3-(t-butyldimethylsiloxy)-7-hydroxy-5-(4-methoxybenzyloxy)-4,4,8-trimethylcyclooctanone 
• 253662-96-3 (4R,5R,7R,8S)-4,8-bis(benzyloxy)-5,9-bis(t-butyldimethylsiloxy)-2,2-dichloro-7-(4-methoxybenzyloxy)-6,6-dimethylnonan-3-one 
• 253662-98-5 (4R,5R,7R,8S)-4,8-bis(benzyloxy)-5,9-bis(t-butyldimethylsiloxy)-2-chloro-7-(4-methoxybenzyloxy)-6,6-dimethylnonan-3-one 
• 333956-98-2 (4R,5R,7R,8S)-4,8-bis(benzyloxy)-5-(t-butyldimethylsiloxy)-2-chloro-9-hydroxy-7-(4-methoxybenzyloxy)-6,6-dimethylnonan-3-one 

Relevant articles and documents

A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals

A highly efficient synthesis of oxygenated 5,5-spiroketals was performed towards the synthesis of the cephalosporolides. Gold(I) chloride in methanol induced the cycloisomerization of a protected alkyne triol with concomitant deprotection to give a strate

A striking exception to the chelate model for acyclic diastereocontrol: Efficient access to a versatile propargyl alcohol for chemical synthesis

The four-step, asymmetric synthesis of a chiral propargyl alcohol 1 from (R)-pantolactone is described. A key feature of the synthesis is a diastereoselective acetylide addition to a chiral α-alkoxy-aldehyde 7, in which unusual Felkin selectivity is obser

N-tert-Butylbenzenesulfenamide-catalyzed oxidation of alcohols to the corresponding carbonyl compounds with N-chlorosuccinimide

N-tert-Butylbenzenesulfenamide (1)-catalyzed oxidation of various primary and secondary alcohols to the corresponding aldehydes and ketones was efficiently carried out by using N-chlorosuccinimide (NCS) in the coexistence of potassium carbonate and molecular sieves 4? at easy-to-control temperatures ranging from 0°C to room temperature. The present catalytic oxidation was performed without giving any damage to the functional groups in alcohols, and was particularly effective in the oxidation of alcohols that formed labile aldehydes because of its mild reaction conditions. Further, selective oxidation of primary hydroxy groups took place in 1-catalyzed oxidation of several diols. Mechanistic investigation suggested that the chlorination of the sulfenamide 1 by NCS led to the formation of a key species, N-tert-butylbenzenesulfinimidoyl chloride (2), which in turn oxidized alcohols in the presence of potassium carbonate to afford carbonyl products by accompanying regeneration of the catalyst 1.