253801-14-8 Usage
Description
N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE, also known as tert-Butyl 5-(hydroxymethyl)isoindoline-2-carboxylate, is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a hydroxymethyl group attached to an isoindoline core and a tert-butyl carbamate protecting group. This structure allows it to be used in the synthesis of complex organic molecules, particularly in the development of drugs targeting specific biological pathways.
Uses
Used in Pharmaceutical Industry:
N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE is used as a key reagent in the synthesis of AT13387, an orally bioavailable clinical candidate. N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE is specifically designed to inhibit heat shock protein 90 (Hsp90), a molecular chaperone that plays a critical role in the stabilization and activation of various client proteins involved in cell survival, growth, and differentiation. Inhibition of Hsp90 has been shown to have therapeutic potential in the treatment of various diseases, including cancer and neurodegenerative disorders.
In the synthesis of AT13387, N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE serves as a building block, providing the necessary structural elements for the formation of the final drug candidate. Its use in this process highlights its importance in the development of novel therapeutic agents with potential applications in various medical fields.
Furthermore, the versatility of N-BOC-5-(HYDROXYMETHYL)-ISOINDOLINE as a reagent may also extend to other areas of pharmaceutical research and development. Its unique structure and functional groups can be exploited in the design and synthesis of new drug candidates targeting different biological pathways and diseases. As a result, this compound has the potential to contribute significantly to the advancement of pharmaceutical sciences and the discovery of new treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 253801-14-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,3,8,0 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 253801-14:
(8*2)+(7*5)+(6*3)+(5*8)+(4*0)+(3*1)+(2*1)+(1*4)=118
118 % 10 = 8
So 253801-14-8 is a valid CAS Registry Number.
253801-14-8Relevant articles and documents
ISOINDOLINE DERIVATIVES WHICH BIND TO AN ATP BINDING SITE
-
Paragraph 00152, (2021/07/31)
The present invention relates to novel probe compounds of formulae I and II defined herein. The present invention also relates to methods of synthesising these novel probe compounds and to their use in assays and screens for determining the binding of a test molecule to the ATP-binding site of a target protein, such as, for example, the Mismatch Repair (MMR) component proteins PMS2 and MLH1, or for determining the location and/or quantity of such target proteins in a biological sample.
Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof
-
, (2017/10/10)
Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.
PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS
-
, (2014/08/06)
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
