253866-88-5

Basic information

• Product Name: Furan, 2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydro-, (2S,5S)-
• CAS NO: 253866-88-5
• Molecular Formula: C13H13FO2
• Molecular Weight: 220.243
• Mol File: 253866-88-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Furan, 2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydro-, (2S,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydro-, (2S,5S)-(253866-88-5)
• EPA Substance Registry System: Furan, 2-ethynyl-5-[(4-fluorophenoxy)methyl]tetrahydro-, (2S,5S)-(253866-88-5)

Safety Data

• Hazardous Substances Data: 253866-88-5(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 254891-68-4 (2S,5S)-5-ethynyl-2-[(p-toluenesulfonyloxy)methyl]tetrahydrofuran 
• 133008-08-9 (4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 
• 104605-98-3 (2S)-2-[(4-fluorophenoxy)methyl]oxirane 
• 1263497-40-0 C₂₉H₃₅FO₄Si 
• 1449521-33-8 O-(2R,3R,5S)-2-[2'-(tert-butyldiphenylsilyloxy)ethyl]-5-[(p-fluorophenoxy)methyl]tetrahydrofuran-3-yl-1H-imidazole-1-carbothioate 
• 1449521-34-9 (2S,5S)-2-[2′-(tert-butyldiphenylsilyloxy)ethyl]-5-[(4-fluorophenoxy)methyl]tetrahydrofuran 
• 1449521-35-0 (2S,5S)-5-[(4-fluorophenoxy)methyl]-2-[1′-hydroxyethyl]tetrahydrofuran 
• 1449521-36-1 (2S,5S)-2-[(4-fluorophenoxy)methyl]-5-[2'-(iodoethyl)]tetrahydrofuran 
• 1449521-37-2 (2S,5S)-2-[(4-fluorophenoxy)methyl]-5-vinyltetrahydrofuran 
• 1449521-38-3 C₁₂H₁₃FO₃ 
• 36326-38-2 ethyl (E)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 133008-09-0 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanal 
• 253866-87-4 (2R,3S,6R)-6-benzenesulfonyloxy-1-chloro-2,3-epoxy-7-(4-fluorophenoxy)heptane 

Downstream Products

• 220623-71-2 (2S,5S)-trans-5-((4-fluorophenoxy)methyl)-2-(1-hydroxy-3-butyn-4-yl)tetrahydrofuran 
• 175212-45-0 (2S,5S)-trans-5-(4-fluorophenoxymethyl)-5-(4-N,O-bis-(phenoxycarbonyl)hydroxylamino-3-butyn-4-yl)tetrahydrofuran 

Relevant articles and documents

Synthesis of (+)-muricatacin and a formal synthesis of CMI-977 from l -malic acid

A total synthesis of (+)-muricatacin and a formal synthesis of CMI-977 have been achieved using commercially available l-malic acid based on our furan approach to oxacyclic systems, the proven scope of which is thus broadened. Georg Thieme Verlag Stuttgart, New York.

Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives

A practically simple and flexible method of making chiral tetrahydrofurans of therapeutic relevance is reported from glyceraldehyde derivatives as chiral synthons. One of the stereocentres is derived from glyceraldehyde derivatives, while the other one is introduced by Sharpless asymmetric epoxidation using either (+)- or (-)-DIPT.

Methods for synthesis of substituted tetrahydrofuran compound

The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.