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25410-78-0

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25410-78-0 Usage

Classification

Potent immunomodulator

Target pathway

IDO pathway

Role in the body

Critical role in immune system suppression

Potential treatment for

Various types of cancer (e.g. melanoma, prostate cancer, pancreatic cancer)

Mechanism of action

Inhibition of the enzyme indoleamine 2,3-dioxygenase (IDO)

Effect on immune response

Enhancement of the immune response against cancer cells

Status in research

Promising results in preclinical and clinical studies

Potential use

Cancer immunotherapy

Check Digit Verification of cas no

The CAS Registry Mumber 25410-78-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,4,1 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 25410-78:
(7*2)+(6*5)+(5*4)+(4*1)+(3*0)+(2*7)+(1*8)=90
90 % 10 = 0
So 25410-78-0 is a valid CAS Registry Number.

25410-78-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-methoxyphenyl)-3H-indol-3-one-N-oxide

1.2 Other means of identification

Product number -
Other names 4-Methoxyphenyl-isatogen

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:25410-78-0 SDS

25410-78-0Downstream Products

25410-78-0Relevant articles and documents

Regioselective Cross-Coupling of Isatogens with Boronic Acids to Construct 2,2-Disubstituted Indolin-3-one Derivatives

Song, Qiuling,Xu, Hetao,Yang, Kai,Ye, Mingxing

supporting information, p. 7776 - 7780 (2021/10/25)

Herein we present a transition-metal-free cross-coupling reaction of isatogens with boronic acids through a 1,4-metalate shift of a boron "ate"complex. This coupling reaction provides a feasible method to deliver valuable 2,2-disubstituted indolin-3-one d

One-Pot Au[III]-/Lewis Acid Catalyzed Cycloisomerization of Nitroalkynes and [3 + 3]Cycloaddition with Donor-Acceptor Cyclopropanes

Dhote, Pawan S.,Ramana, Chepuri V.

supporting information, p. 6221 - 6224 (2019/08/26)

A one-pot protocol for the synthesis of a tricyclic pseudoindoxyl scaffold from 2-nitroalkynylbenzenes, comprising of an Au(III)-catalyzed nitroalkyne cycloisomerization leading to isatogen and its [3 + 3]-cycloaddition with donor-acceptor cyclopropanes m

A combined experimental and density functional theory study on the Pd-mediated cycloisomerization of o-alkynylnitrobenzenes - Synthesis of isatogens and their evaluation as modulators of ROS-mediated cell death

Ramana, Chepuri V.,Patel, Pitambar,Vanka, Kumar,Miao, Benchun,Degterev, Alexei

, p. 5955 - 5966 (2011/03/17)

Highly selective cycloisomerization of o-alkynylnitrobenzenes, leading to isatogens, has been achieved by employment of a PdII complex. This reaction is very general and functional-group-tolerant. The possible mechanism of this reaction was inv

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