255735-88-7

Basic information

• Product Name: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI);(2-Aminopropyl)carbamic acid tert-butyl ester;CarbaMic acid, (2-aMinopropyl)-, 1,1-diMethylethyl ester;CarbaMic acid, N-(2-aMinopropyl)-, 1,1-diMethylethyl ester
• CAS NO: 255735-88-7
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.24072
• Product Categories: N-BOC
• Mol File: 255735-88-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 263.719 °C at 760 mmHg
• Flash Point: 113.293 °C
• Appearance: /
• Density: 0.984g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DCM, Hexane, Ethyl Acetate
• PKA: 12.51±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)(255735-88-7)
• EPA Substance Registry System: Carbamic acid, (2-aminopropyl)-, 1,1-dimethylethyl ester (9CI)(255735-88-7)

Safety Data

• Hazardous Substances Data: 255735-88-7(Hazardous Substances Data)

Usage

Uses

(2-Aminopropyl)carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of Misoprostol (M368755), an cytoprotective prostaglandin PGE analogue.

InChI:InChI=1/C8H18N2O2/c1-6(9)5-10-7(11)12-8(2,3)4/h6H,5,9H2,1-4H3,(H,10,11)

Upstream product

• 6627-89-0 tert-butyl phenyl carbonate 
• 78-90-0 1,2-diaminopropan 
• 24424-99-5 di-tert-butyl dicarbonate 
• 110-89-4 piperidine 
• 149602-64-2 1-azido-2-(N-tert-butoxycarbonylamino)propane 
• 13303-10-1 tert-Butyl 4-nitrophenyl carbonate 

Downstream Products

• 851017-82-8 3-[(2-benzyloxycarbonyl-ethyl)-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-amino]-propionic acid benzyl ester 
• 1003577-91-0 tert-butyl (2-{[(4-ethoxyphenyl)carbonyl]amino}-propyl)carbamate 
• 1003577-93-2 tert-butyl [2-({[1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]carbonyl}amino)propyl]carbamate 
• 1059191-59-1 tert-Butyl (2-{[7-(2,4-dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}propyl)carbamate 
• 851017-84-0 3-[(2-benzyloxycarbonyl-ethyl)-(2-{3-[(2-{2-[bis-(2-benzyloxycarbonyl-ethyl)-amino]-propylcarbamoyl}-ethyl)-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-amino]-propionylamino}-1-methyl-ethyl)-amino]-propionic acid benzyl ester 

Relevant articles and documents

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials?

The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC50 = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC50 = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC50 = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors.

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor