2561-25-3

Basic information

• Product Name: 1-(4-Fluorophenoxy)-4-nitrobenzene
• Synonyms: 1-(4-Fluorophenoxy)-4-nitrobenzene;1-(4-Fluorophenoxybenzyl)-4-nitrobenzene
• CAS NO: 2561-25-3
• Molecular Formula: C₁₂H₈FNO₃
• Molecular Weight: 233.1952232
• Mol File: 2561-25-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 318.2°C at 760 mmHg
• Flash Point: 146.2°C
• Appearance: /
• Density: 1.324g/cm³
• Vapor Pressure: 0.000684mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 1-(4-Fluorophenoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenoxy)-4-nitrobenzene(2561-25-3)
• EPA Substance Registry System: 1-(4-Fluorophenoxy)-4-nitrobenzene(2561-25-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 2561-25-3(Hazardous Substances Data)

Usage

General Description

1-(4-Fluorophenoxy)-4-nitrobenzene is a chemical compound with the molecular formula C12H8FNO3. It is a pale yellow solid with a molecular weight of 221.19 g/mol. 1-(4-Fluorophenoxy)-4-nitrobenzene is used in the production of various pharmaceuticals, agrochemicals, and dyes. It has been studied for its potential use as a building block in organic synthesis and as a starting material for the development of new chemical compounds. 1-(4-Fluorophenoxy)-4-nitrobenzene has also been found to possess some biological activity, making it of interest for further research in medicinal chemistry.

InChI:InChI=1/C12H8FNO3/c13-9-1-5-11(6-2-9)17-12-7-3-10(4-8-12)14(15)16/h1-8H

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 371-41-5 4-Fluorophenol 
• 350-46-9 4-Fluoronitrobenzene 
• 586-78-7 para-nitrophenyl bromide 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 129121-41-1 2-amino-6-(4'-fluorophenoxy)-benzothiazole 
• 957826-34-5 [4-(4-fluoro-phenoxy)-phenyl]-(2-nitro-phenyl)-amine 
• 957826-35-6 N¹-(4-(4-fluorophenoxy)phenyl)benzene-1,2-diamine 
• 1433050-67-9 (2R,3S)-3-(2-(4-(4-fluorophenoxy)phenyl)pyrimidin-4-yl)-2,3-dihydroxypropanamide 
• 1433052-13-1 C₂₁H₁₉FN₂O₅ 
• 1367124-29-5 (R)-1-{4-((R)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol 
• 1367124-43-3 (S)-1-{4-((S)-1,2-dihydroxy-ethyl)-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-yl}-ethane-1,2-diol 
• 1367126-23-5 2-[4-(4-fluoro-phenoxy)-phenyl]-4,6-divinyl-pyridine 
• 1367126-21-3 2,4-dichloro-6-[4-(4-fluoro-phenoxy)-phenyl]-pyridine 
• 1367126-19-9 C₂₂H₂₁FN₂O₃ 
• 1367125-23-2 (S)-2-({6-[4-(4-fluoro-phenoxy)-phenyl]-pyridin-2-ylmethyl}-amino)propionamide 
• 1367125-59-4 6-(4-(4-fluorophenoxy)phenyl)-1',2',3',6'-tetrahydro-[4,4'-bipyridine]-2-carboxamide 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY

The present invention provides a novel heterocyclic compound represented by Formula [I] and a salt thereof: wherein the symbols are as defined in the specification, which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels

Both N- and T-type calcium ion channels have been implicated in pain transmission and the N-type channel is a well-validated target for the treatment of neuropathic pain. An SAR investigation of a series of substituted aminobenzothiazoles identified a subset of five compounds with comparable activity to the positive control Z160 in a FLIPR-based intracellular calcium response assay measuring potency at both CaV2.2 and CaV3.2 channels. These compounds may form the basis for the development of drug leads and tool compounds for assessing in vivo effects of variable modulation of CaV2.2 and CaV3.2 channels.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is