256369-34-3

Basic information

• Product Name: 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate
• Synonyms: 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate;3-Aza-Bicyclo[3.1.0]Hexan-6-AMine Bis(4-Methylbenzenesulfonic Acid) Salt;KCCNGGYEEHPDGW-HNTGFMDNSA-N
• CAS NO: 256369-34-3
• Molecular Formula: C12H18N2O3S
• Molecular Weight: 270.34792
• Mol File: 256369-34-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate(256369-34-3)
• EPA Substance Registry System: 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate(256369-34-3)

Safety Data

• Hazardous Substances Data: 256369-34-3(Hazardous Substances Data)

Usage

General Description

3-Azabicyclo[3.1.0]hexan-6-amine 4-methylbenzenesulfonate is a chemical compound that consists of a bicyclic amine and a methylbenzenesulfonate group. The bicyclic amine is a heterocyclic compound that contains a nitrogen atom and two carbon atoms arranged in a bicycle-like structure. 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate is often used as a building block in organic synthesis and can be used to create pharmaceuticals, agrochemicals, and other complex molecules. The 4-methylbenzenesulfonate group is a sulfonic acid derivative that is commonly used as a protecting group in organic synthesis to block reactive sites on molecules. 3-azabicyclo[3.1.0]hexan-6-aMine 4-Methylbenzenesulfonate has a wide range of applications in chemical and pharmaceutical industries, and its unique structure makes it a valuable tool for creating diverse chemical compounds.

Upstream product

• 185559-52-8 (1α,5α,6α)-3-N-benzyl-6-[t-butoxycarbonylamino]-3-aza-bicyclo[3.1.0]hexane 
• 151860-15-0 (1α,5α,6α)-3-N-benzyl-6-nitro-2,4-dioxo-3-azabicyclo[3.1.0]hexane 
• 151860-16-1 (1α,5α,6α)-3-N-benzyl-6-nitro-3-azabicyclo[3.1.0]hexane 
• 151860-17-2 (1α,5α,6α)-3-N-benzyl-6-amino-3-aza-bicyclo[3.1.0]hexane 
• 104-15-4 toluene-4-sulfonic acid 
• 134575-17-0 tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate 

Relevant articles and documents

Synthesis of trovafloxacin using various (1α,5α,6α)-3-azabicyclo[3.1.0]hexane derivatives

Trovafloxacin, a novel broad spectrum antibacterial, contains the unusual (1α,5α,6α)-3-azabicyclo[3.1.0]hexane ring system. The prototype of the industrial synthesis of this ring system and possible mechanistic pathways to exclusive formation of the exo or 6α-nitro derivative 4 are described, which leads to the key 6a-nitro-3-azabicyclo[3.1.0]hexane intermediate 10. The synthesis of 6a-amino-3-azabicyclo[3.1.0]hexane 16 and useful protected cxo 6-amino derivatives 15 and 17 follows from 10. These can be coupled with the 7-chloronaphthyridone 18 to yield protected trovafloxacin compounds 20-22 in good yield. The ethyl ester of trovafloxacin 21 can also be accessed from the product of coupling 19, derived from 18 and the exo 6-nitro-3-azabicyclo[3.1.0]hexane compound 12. Removal of protecting groups from 20-22 with methanesulfonic acid yields trovafloxacin mesylate from which trovafloxacin zwitterion 1 can be liberated with base treatment. Zwitterion l can also be prepared directly from 16 tosylate salt and naphthyridone-2-carboxylic acid 26. The Royal Society of Chemistry 2000.