2564-07-0

Basic information

• Product Name: 2-CHLORO-N-(2,3-DIMETHYL-PHENYL)-ACETAMIDE
• Synonyms: CHEMBRDG-BB 3015630;ART-CHEM-BB B015630;AKOS BBS-00004041;AKOS B015630;2-CHLORO-N-(2,3-DIMETHYL-PHENYL)-ACETAMIDE;2-chloro-N-(2,3-dimethylphenyl)acetamide(SALTDATA: FREE);2-chloro-N-(2,3-dimethylphenyl)ethanamide;NSC166431
• CAS NO: 2564-07-0
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66
• Mol File: 2564-07-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 135-136
• Boiling Point: 333.1 °C at 760 mmHg
• Flash Point: 155.2 °C
• Appearance: /
• Density: 1.187 g/cm³
• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.91±0.70(Predicted)
• CAS DataBase Reference: 2-CHLORO-N-(2,3-DIMETHYL-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2,3-DIMETHYL-PHENYL)-ACETAMIDE(2564-07-0)
• EPA Substance Registry System: 2-CHLORO-N-(2,3-DIMETHYL-PHENYL)-ACETAMIDE(2564-07-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 2564-07-0(Hazardous Substances Data)

Usage

Uses

2-Chloro-N-(2,3-dimethylphenyl)acetamide has been used as a reactant in the preparation of quinoxalinyl thioether derivatives with antibacterial and antifungal activity.

InChI:InChI=1/C10H12ClNO/c1-7-4-3-5-9(8(7)2)12-10(13)6-11/h3-5H,6H2,1-2H3,(H,12,13)

Upstream product

• 87-59-2 2,3-Dimethylaniline 
• 95-64-7 4-amino-o-xylene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 133168-00-0 piperidino-acetic acid-(2,3-dimethyl-anilide) 
• 109099-67-4 N,N-dimethyl-glycine-(2,3-dimethyl-anilide) 
• 717139-54-3 N-(2,3-dimethyl-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide 
• 1190213-55-8 2-(4-(3,4-dichlorophenyl)-1,2,3-selenadiazol-5-ylthio)-N-(2,3-dimethylphenyl)acetamide 
• 1446270-28-5 (S)-2-((2, 3-dimethylphenyl)amino)-2-oxoethyl(2-oxotetrahydrofuran-3-yl)carbamodithioate 
• 1304771-73-0 2-(2-methylquinoxalin-3-ylthio)-N-(2,3-dimethylphenyl)acetamide 
• 1188890-70-1 2-(4-(2,4-dibromophenyl)-1,2,3-thiadiazol-5-ylthio)-N-(2,3-dimethylphenyl)acetamide 
• 1198271-75-8 N-(2,3-dimethylphenyl)-2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)acetamide 
• 1018074-61-7 C₁₈H₁₆Cl₂FN₅OS 

Relevant articles and documents

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

Ether acetamide derivative containing alpha-carbonyl amide structure and application of ether acetamide derivative

The invention discloses application of an ether acetamide derivative containing an alpha-carbonyl amide structure in an aspect of resisting plant diseases. The structure is shown in a general formulaI. Limitation of groups such as R and R is shown as the specification. A compound shown in the general formula I has a function of preventing and treating the plant diseases, and TMV, rice bacterial blight, citrus canker, ralstonia solanacearum and other plant virus diseases can be prevented and treated.

Design, synthesis and antibacterial evaluation of novel AHL analogues

Two series of novel AHL analogues were designed, synthesized and evaluated for antibacterial activity under cell membrane conditions in vitro. Analogues 4a-c and 4g-m presented potent activity against Gram-positive bacteria. Especially the analogue 4l exe