256447-08-2

Basic information

• Product Name: AC2-12
• Synonyms: Annexin A1 (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine) Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine);Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine);Annexin A1;ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit;ANX1;LPC1;Annexin 1 (ANXA - 1;Annexin A1 (1-11) (dephosphorylated)
• CAS NO: 256447-08-2
• Molecular Formula: C63H94N14O17S
• Molecular Weight: 1351.57
• Product Categories: peptide
• Mol File: 256447-08-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: AC2-12(CAS DataBase Reference)
• NIST Chemistry Reference: AC2-12(256447-08-2)
• EPA Substance Registry System: AC2-12(256447-08-2)

Safety Data

• Hazardous Substances Data: 256447-08-2(Hazardous Substances Data)

Usage

Enzyme inhibitor

This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.