256477-09-5 Usage
Description
UK-371804 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor, demonstrating excellent selectivity over tPA, plasmin, Factor IXa, and Xa. It has shown the ability to inhibit exogenous uPA in human chronic wound fluid and penetrate into wounds with no adverse effects on wound healing parameters, making it a potential treatment for chronic dermal ulcers.
Uses
Used in Pharmaceutical Industry:
UK-371804 is used as a therapeutic agent for the treatment of chronic dermal ulcers due to its ability to inhibit exogenous uPA activity in human chronic wound fluid and penetrate into wounds without negatively affecting wound healing parameters.
Used in Wound Care:
UK-371804 is used as a wound healing enhancer, as it can inhibit exogenous uPA activity in wounds, potentially improving the healing process for patients with chronic dermal ulcers.
Used in Research and Development:
UK-371804 serves as a valuable research tool for studying the role of uPA in various physiological and pathological processes, as well as for developing new therapeutic strategies targeting uPA-mediated pathways.
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
Check Digit Verification of cas no
The CAS Registry Mumber 256477-09-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,4,7 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 256477-09:
(8*2)+(7*5)+(6*6)+(5*4)+(4*7)+(3*7)+(2*0)+(1*9)=165
165 % 10 = 5
So 256477-09-5 is a valid CAS Registry Number.