25683-09-4 Usage
Description
(R)-2-amino-3-(tritylthio)propanoic acid, with the molecular formula C21H21NO2S, is an amino acid derivative featuring a propanoic acid group, a tritylthio group, and an amino group. (R)-2-aMino-3-(tritylthio)propanoic acid is widely recognized for its applications in organic synthesis and pharmaceutical research, where it serves as a fundamental building block for the development of various pharmaceuticals and biochemicals. Its potential therapeutic applications in treating a range of diseases and disorders, along with its anti-inflammatory and anti-cancer properties, make it a significant subject of interest within the field of medicinal chemistry.
Uses
Used in Pharmaceutical Research:
(R)-2-amino-3-(tritylthio)propanoic acid is used as a building block in the pharmaceutical industry for the synthesis of various pharmaceuticals and biochemicals. Its unique structure and functional groups contribute to the development of novel compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-2-amino-3-(tritylthio)propanoic acid is utilized as a key component in the creation of complex organic molecules. Its versatile structure allows for a range of reactions and modifications, making it a valuable asset in the synthesis of diverse chemical compounds.
Used in Medicinal Chemistry:
(R)-2-amino-3-(tritylthio)propanoic acid is employed as a subject of study in medicinal chemistry due to its potential therapeutic applications. Its anti-inflammatory and anti-cancer properties are of particular interest, as they may lead to the development of new treatments for various diseases and disorders.
Used in Drug Development:
(R)-2-aMino-3-(tritylthio)propanoic acid is also used in drug development as a starting material or intermediate for the synthesis of new drugs. Its unique properties and reactivity make it a promising candidate for the creation of innovative pharmaceuticals with improved efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 25683-09-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,6,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25683-09:
(7*2)+(6*5)+(5*6)+(4*8)+(3*3)+(2*0)+(1*9)=124
124 % 10 = 4
So 25683-09-4 is a valid CAS Registry Number.
25683-09-4Relevant articles and documents
Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents
Koike, Kota,Nagano, Masanobu,Ebihara, Masahiro,Hirayama, Tasuku,Tsuji, Mieko,Suga, Hiroaki,Nagasawa, Hideko
, p. 4022 - 4046 (2020/06/08)
By carrying out structural modifications based on the bicyclic peptide structure of echinomycin, we successfully synthesized various powerful antitumor derivatives. The ring conformation in the obtained compounds was restricted by cross-linking with an unnatural bond. The prepared derivatives were demonstrated to strongly suppress the hypoxia inducible factor (HIF)-1 transcriptional activation and hypoxia induction of HIF-1 protein expression. Particularly, alkene-bridged derivative 12 exhibited remarkably potent cytotoxicity (IC50 = 0.22 nM on the MCF-7 cell line) and HIF-1 inhibition (IC50 = 0.09 nM), which considerably exceeded those of echinomycin. Conformational analyses and molecular modeling studies revealed that the biological activities were enhanced following restriction of the conformation by cross-linking through a metabolically stable and rigid bridge bond. In addition, we proposed a new globular conformation stabilized by intramolecular πstacking that can contribute to the biological effects of bicyclic depsipeptides. The developments presented in the current study serve as a useful guide to expand the chemical space of peptides in drug discovery.
seco-Cyclothialidines: New concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties
Rudolph,Theis,Hanke,Endermann,Johannsen,Geschke
, p. 619 - 626 (2007/10/03)
seco-Cyclothialidines are a promising class of bacterial DNA gyrase B subunit inhibitors. A new seco-cyclothialidine derivative containing a dioxazine moiety, BAY 50-7952, was synthesized through a new concise pathway. One key step of the synthesis is the
