2582-30-1 Usage
Chemical Properties
White to off-white crystalline powder. It is almost insoluble in water, alcohol and other acids.
Uses
Aminoguanidine bicarbonate (AGB) is of practical importance because of its use in dyes, dispersants, explosives and other commercial applications. It is used in the synthesis of antitumor agents and antileukemic activity. Also used in the synthesis of neuraminidase inhibitors in the inhibition of influenze.
Application
Aminoguanidine bicarbonate is an inhibitor of NOS (nitric oxide synthase). Aminoguanidine bicarbonate is used to study the effect of addition of polyamines to rat embryo cell cultures infected with adenovirus type 5.
Biochem/physiol Actions
Aminoguanidine bicarbonate protects the cells infected with adenovirus from chromosomal damage. Aminoguanidine is a specific and highly effective inhibitor of diamine oxidase present in fetal calf serum.
Synthesis
A synthesis method of aminoguanidine bicarbonate includes reacting an acidic aqueous hydrazine hydrate solution with calcium cyanamide in an elevated temperature to produce an aminoguanidine solution, recovering the solution, and reacting therewith an alkali metal bicarbonate to produce relatively high purity aminoguanidine bicarbonate.
Check Digit Verification of cas no
The CAS Registry Mumber 2582-30-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,8 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2582-30:
(6*2)+(5*5)+(4*8)+(3*2)+(2*3)+(1*0)=81
81 % 10 = 1
So 2582-30-1 is a valid CAS Registry Number.
InChI:InChI=1/CH6N4.CH2O3/c2-1(3)5-4;2-1(3)4/h4H2,(H4,2,3,5);(H2,2,3,4)/p-2
2582-30-1Relevant articles and documents
The synthesis of 5,7-dimethyl-1,2,4-triazolo[1,5a(14C)] pyrimidine-2-carbaldehyde from [14C]aminoguanidine: A key intermediate for the radiochemical GMP synthesis of a drug candidate
Rane, Anil M.,Klaas, Schildknegt
scheme or table, p. 257 - 260 (2011/05/06)
Hydrazination of barium [14C]cyanamide and hydrazinolysis of S-methylisothio[14C]urea were compared for their ability to efficiently prepare [14C]aminoguanidine bicarbonate. [ 14C]Aminoguanidine bicarbonate was converted in three steps to 5, 7-dimethyl-1,2,4-triazolo[1,5a(14C)]pyrimidine-2-carbaldehyde, a key radiochemical GMP starting material. Copyright
Aminoguanidine bicarbonate with particular properties and method for making same
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Page/Page column 3, (2010/02/11)
The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding with an amount of cyamide slightly higher than the stoichiometric quantity. The invention also concerns quasi-spherical agglomerates of aminoguanidine bicarbonate crystals.
Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole
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, (2008/06/13)
A method for producing 3-amino-5-mercapto-1,2,4-triazole, useful as an intermediate compound for a medicine or pesticide, or the intermediate thereof, a salt of N-guanidino thiourea from aminoguanidine thiocyanate or a thiocyanate and an aminoguanidine compound in the presence of an acid in a polar solvent, or even from hydrazine and cyanamide is disclosed.
