25823-49-8

Basic information

• Product Name: 5,6-DIHYDROBENZO[H]CINNOLIN-3(2H)-ONE
• Synonyms: 5,6-DIHYDROBENZO[H]CINNOLIN-3(2H)-ONE;2H,3H,5H,6H-benzo[h]cinnolin-3-one
• CAS NO: 25823-49-8
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.22
• Mol File: 25823-49-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.34g/cm³
• Refractive Index: 1.705
• CAS DataBase Reference: 5,6-DIHYDROBENZO[H]CINNOLIN-3(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDROBENZO[H]CINNOLIN-3(2H)-ONE(25823-49-8)
• EPA Substance Registry System: 5,6-DIHYDROBENZO[H]CINNOLIN-3(2H)-ONE(25823-49-8)

Safety Data

• Hazardous Substances Data: 25823-49-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H10N2O/c15-11-7-9-6-5-8-3-1-2-4-10(8)12(9)14-13-11/h1-4,7H,5-6H2,(H,13,15)

Upstream product

• 308339-67-5 (1,2,3,4-Tetrahydro-1-oxo-2-naphthalenylidene)-acetic acid 
• 6000-59-5 glyoxalic acid monohydrate 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 298-12-4 Glyoxilic acid 
• 100519-22-0 α-hydroxy-α-<1-oxo-1,2,3,4-tetrahydronaphth-2-yl>acetic acid 
• 230307-41-2 4-hydroxy-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one 
• 25823-48-7 4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-one 
• 6742-31-0 1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid 

Downstream Products

• 25823-50-1 3-chloro-5,6-dihydrobenzocinnoline 

Relevant articles and documents

Synthesis, structure-activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors

Through a cell-based biological screening, the benzocinnolinone derivative (±)-2c was identified as a promising STAT3 inhibitor. Since SAR studies on a series of compounds structurally related to (±)-2c (1c, 2a-p, 3c, 4c, 6) showed that the latter had the

PYRIDAZINE COMPOUNDS AND METHODS

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of

Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1β, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.