258825-18-2

Basic information

• Product Name: methyl (2R,2'R)-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate
• Synonyms: methyl (2R,2'R)-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate
• CAS NO: 258825-18-2
• Molecular Weight: 291.347
• Mol File: 258825-18-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (2R,2'R)-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2R,2'R)-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate(258825-18-2)
• EPA Substance Registry System: methyl (2R,2'R)-2-phenyl-2-(N-methoxycarbonyl-2'-piperidyl)acetate(258825-18-2)

Safety Data

• Hazardous Substances Data: 258825-18-2(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 

Downstream Products

• 40431-64-9 dexmethylphenidate 
• 19262-68-1 dexmethylphenidate hydrochloride 

Relevant articles and documents

A convenient method for synthesis of enantiomerically enriched methylphenidate from N-methoxycarbonylpiperidine

(equation presented) This report describes a new method to prepare optically active methylphenidate starting from piperidine. The method consists of a transformation of N-methoxycarbonylpiperidine to the corresponding α-methoxylated carbamate I by utilizing electrochemical oxidation followed by the coupling reaction with optically active Evans imides II to produce optically active methylphenidate derivatives III with high stereoselectivities. threo-(2R,2′R)-Methylphenidate (IV; Ar=Ph; Ritalin) was easily prepared from III in three steps.