259100-41-9

Basic information

• Product Name: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 2-amino-5-[[(2,3-difluorophenyl)methyl]thio]-
• CAS NO: 259100-41-9
• Molecular Formula: C12H8F2N4OS2
• Molecular Weight: 326.351
• Mol File: 259100-41-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 2-amino-5-[[(2,3-difluorophenyl)methyl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 2-amino-5-[[(2,3-difluorophenyl)methyl]thio]-(259100-41-9)
• EPA Substance Registry System: Thiazolo[4,5-d]pyrimidin-7(4H)-one, 2-amino-5-[[(2,3-difluorophenyl)methyl]thio]-(259100-41-9)

Safety Data

• Hazardous Substances Data: 259100-41-9(Hazardous Substances Data)

Upstream product

• 127199-95-5 2-amino-5-mercapto-thiazolo[4,5-d]pyrimidin-7-ol 
• 676345-24-7 C₁₂H₈F₂N₄OS₂ 
• 127199-95-5 2-Amino-5-mercapto-thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 113211-94-2 2,3-difluorobenzyl bromide 
• 127199-95-5 5-amino-1,2,3,7-tetrahydro-7-oxo-2-thioxothiazolo<4.5-d>-pyrimidine 
• 676345-24-7 4-amino-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinyl ester thiocyanic acid 
• 503271-69-0 6-amino-2-[[(2,3-difluorophenyl)methyl]thio]-4(3H)-pyrimidinone 
• 259100-47-5 2-amino-5-(benzylsulfanyl)[1,3]thiazolo[4,5-d]pyrimidin-7-ol 
• 259103-40-7 {[4-amino-2-(benzylsulfanyl)-6-hydroxypyrimidin-5-yl]sulfanyl}formonitrile 

Downstream Products

• 259103-43-0 7-chloro-5-[(2,3-difluorobenzyl)sulfanyl][1,3]thiazolo[4,5-d]pyrimidin-2-amine 
• 259101-64-9 5-[[(2,3-Difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 676345-71-4 2-({2-chloro-5-[((2,3-difluorophenyl)methyl)thio]thiazolo[4,5-d]pyrimidin-7-yl}amino)-(2S,3S)-butane-1,3-diol 
• 676345-69-0 5-[((2,3-difluorophenyl)methyl)thio]-7-{[(1S,2S)-2-hydroxy-1-(hydroxymethyl)propyl]amino}thiazolo[4,5-d]pyrimidin-2(3H)-one 
• 676345-23-6 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one, monosodium salt 
• 676345-25-8 2-[[2-chloro-5-[[(2,3-difluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1,3-propanediol 

Relevant articles and documents

Evaluation of a series of bicyclic CXCR2 antagonists

The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alternat

NOVEL COMPOUND

A compound of formula (I) and pharmaceutically acceptable salts or solvates thereof for use in therapy.

Thiazolo (4,5-D) pyrimidine compounds

The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therap