25912-50-9 Usage
Description
3-Aminocyclohexanecarboxylic acid is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and bioactive molecules. It is characterized by its unique cyclic structure and amino and carboxylic acid functional groups, which contribute to its reactivity and potential applications in medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
3-Aminocyclohexanecarboxylic acid is used as a key intermediate for the preparation of PF-04449913, a potent and orally bioavailable Smoothened inhibitor with potential antitumor properties. 3-Aminocyclohexanecarboxylic acid plays a significant role in the development of cancer therapeutics by targeting the Hedgehog signaling pathway, which is implicated in various malignancies.
Additionally, 3-Aminocyclohexanecarboxylic acid is utilized in the synthesis of functionalized glutaramides, which are selective inhibitors of neutral endopeptidase. These inhibitors are being explored for the treatment of female sexual arousal disorder, highlighting the compound's versatility in addressing different medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 25912-50-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,9,1 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25912-50:
(7*2)+(6*5)+(5*9)+(4*1)+(3*2)+(2*5)+(1*0)=109
109 % 10 = 9
So 25912-50-9 is a valid CAS Registry Number.
25912-50-9Relevant articles and documents
An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid
Badland, Matthew,Bains, Carol A.,Howard, Roger,Laity, Daniel,Newman, Sandra D.
experimental part, p. 864 - 866 (2010/11/02)
An improved synthesis of (1R,3S)-3-[(tert-butoxycarbonyl)amino] cyclohexanecarboxylic acid from 3-aminobenzoic acid is described utilising milder and more selective conditions. Both a classical salt resolution and an enzymatic approach have been shown to give the desired compound in high selectivity.
New cyclic peptide assemblies with hydrophobic cavities: The structural and thermodynamic basis of a new class of peptide nanotubes
Amorin, Manuel,Castedo, Luis,Granja, Juan R.
, p. 2844 - 2845 (2007/10/03)
A new class of self-assembling peptides based on cyclic peptides made of alternating 3-aminocyclohexanecarboxylic acid (γ-Acc) and α-amino acids is described. The studied cylindrical assemblies are models for a new class of self-assembling peptide nanotub
2-aminopyridine derivatives and combinatorial libraries thereof
-
, (2008/06/13)
The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
