2598-31-4

Basic information

• Product Name: 1-(8-hydroxyquinolin-5-yl)ethanone
• Synonyms: 1-(8-hydroxyquinolin-5-yl)ethanone;Quinacetol;5-Acetyl-8-hydroxyquinoline;5-Acetyl-8-quinolinol;5-Acetyloxine;8-Hydroxy-5-quinolyl Methyl Ketone;NSC 40901;NSC 523017
• CAS NO: 2598-31-4
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.2
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 2598-31-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 110-112°C
• Boiling Point: 321.94°C (rough estimate)
• Flash Point: 205.7°C
• Appearance: /
• Density: 1.1963 (rough estimate)
• Vapor Pressure: 1.57E-07mmHg at 25°C
• Refractive Index: 1.4900 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 1-(8-hydroxyquinolin-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(8-hydroxyquinolin-5-yl)ethanone(2598-31-4)
• EPA Substance Registry System: 1-(8-hydroxyquinolin-5-yl)ethanone(2598-31-4)

Safety Data

• Hazardous Substances Data: 2598-31-4(Hazardous Substances Data)

Usage

Chemical Properties

Pale Brown Solid

Uses

Quinacetol (cas# 2598-31-4) is a compound useful in organic synthesis.

InChI:InChI=1/C11H9NO2/c1-7(13)8-4-5-10(14)11-9(8)3-2-6-12-11/h2-6,14H,1H3

Upstream product

• 2598-29-0 8-acetyloxyquinoline 
• 1261470-46-5 C₉H₆INO 
• 148-24-3 8-quinolinol 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 57434-96-5 5-acetyl-8-hydroxyquinoline hydrochloride 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 102024-19-1 1-(8-hydroxy-quinolin-5-yl)-5-phenyl-penta-2,4-dien-1-one 
• 101607-19-6 3t-(4-chloro-phenyl)-1-(8-hydroxy-[5]quinolyl)-propenone 
• 15462-67-6 1-(8-hydroxy-[5]quinolyl)-3t-(3-nitro-phenyl)-propenone 
• 109559-55-9 1-(8-hydroxy-quinolin-5-yl)-3-(4-nitro-phenyl)-propenone 
• 15462-66-5 3t-(3,4-dimethoxy-phenyl)-1-(8-hydroxy-[5]quinolyl)-propenone 
• 102041-09-8 1-(8-Hydroxychinol-5-yl)-3-phenylpropan-1,3-dion 
• 112519-11-6 5-{1-[(Z)-4-Chloro-phenylimino]-ethyl}-quinolin-8-ol 
• 101895-45-8 1-(8-hydroxy-quinolin-5-yl)-3-(4-methoxy-phenyl)-propenone 
• 112519-10-5 5-{1-[(Z)-4-Methoxy-phenylimino]-ethyl}-quinolin-8-ol 
• 112519-02-5 5-{1-[(Z)-Phenylimino]-ethyl}-quinolin-8-ol 
• 26872-48-0 1-(8-benzyloxyquinolin-5-yl)ethanone 
• 102656-46-2 3t-(3,4-dimethoxy-phenyl)-1-(7-dimethylaminomethyl-8-hydroxy-[5]quinolyl)-propenone 

Relevant articles and documents

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Synthesis, characterization, crystallographic studies of 5-acetyl-8-hydroxyquinoline and their chalcone derivatives

An efficient, easy and one pot synthesis for the Friedel-Craft acetylation reaction of quinolines was developed. The reaction between 8-hydroxyquinoline and acetyl/benzoyl chloride in nitrobenzene immediately flocculates as yellow precipitate. On further

NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF

8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxymethyl, 8- phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof are described that exhibit iron chelation, neuroprotective, neurorestorative, apoptotic and/or selective MAO-AB inhibitory activities.

PROCESS FOR PREPARING ISOMERS OF CARMOTEROL

A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, heterocyclic, alkenyl, benzocycloalkyl, aralkyl, haloarylalkyl, heteroaralkyl, haloalkyl, alkoxyaralkyl, substituted silyl and benzyl; and R2 is hydrogen, optionally substituted silyl or optionally substituted benzyl. Formula (I), (II) and (III): There is also described a process for preparing (R,R)-carmoterol from compound (III).