25980-24-9Relevant articles and documents
Synthesis and antimicrobial activity of some new substituted quinoxalines
El-Atawy, Mohamed A.,Hamed, Ezzat A.,Alhadi, Mahjoba,Omar, Alaa Z.
, (2019/11/28)
A number of new symmetrically and asymmetrically 2,3-disubstituted quinoxalines were synthesized through functionalization of 2,3-dichloroquinoxaline (2,3-DCQ) with a variety of sulfur and/or nitrogen nucleophiles. The structures of the obtained compounds were established based on their spectral data and elemental analysis. The antimicrobial activity for the prepared compounds was investigated against four bacterial species and two fungal strains. The symmetrically disubstituted quinoxalines 2, 3, 4, and 5 displayed the most significant antibacterial activity, while compounds 6a, 6b, and the pentacyclic compound 10 showed considerable antifungal activity. Furthermore, compounds 3f, 6b showed broad antimicrobial spectrum against most of the tested strains.
ARYLAMINE SUBSTUTUTED QUINOXALINE AND THEIR USE AS ANTICANCER DRUGS
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Paragraph 0053-0055; 0058, (2016/10/09)
The present invention provides new compounds of formula I and II, which have potential of protein phosphatase 2A (PP2A) agonistt, CIP2A inhibitor and SET antagonist. Also provided are treatment methods using the compounds of formula I and II.
