260061-31-2

Basic information

• Product Name: 2-Pyrrolidinone, 4-methyl-, (4R)-
• CAS NO: 260061-31-2
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Mol File: 260061-31-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 4-methyl-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 4-methyl-, (4R)-(260061-31-2)
• EPA Substance Registry System: 2-Pyrrolidinone, 4-methyl-, (4R)-(260061-31-2)

Safety Data

• Hazardous Substances Data: 260061-31-2(Hazardous Substances Data)

Usage

General Description

2-Pyrrolidinone, 4-methyl-, (4R)- is a chemical compound with the molecular formula C5H9NO. It is a colorless liquid with a mild odor. 2-Pyrrolidinone, 4-methyl-, (4R)- has been found to have various industrial and commercial applications, including as a solvent, a chemical intermediate in the production of pharmaceuticals, and in the manufacturing of polymers and plastics. It is also used in the production of pesticides and herbicides. Additionally, 2-Pyrrolidinone, 4-methyl-, (4R)- has been studied for its potential health effects, and it is important to handle and use this compound with proper safety precautions.

Upstream product

• 1443453-36-8 (4R)-4-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 1443453-34-6 diethyl 2-[(2R)-1-nitropropan-2-yl]propanedioate 
• 1443453-35-7 ethyl (4R)-4-methyl-2-oxopyrrolidine-3-carboxylate 
• 492435-28-6 (2S,5S)-N-allyl-2-(tert-butyldimethylsilyl)oxy-5-phenyl-2-(phenylseleno)acetyl-1,3-oxazolidin-4-one 
• 492435-20-8 (S)-(+)-O-(phenylseleno)acetyl-N-allylmandelamide 
• 162103-41-5 (1'S,4R)-4-methyl-1-(1-phenyleth-1'-yl)pyrrolidin-2-one 
• 492435-27-5 (2S,5S)-N-allyl-2-(tert-butyldimethylsilyl)oxy-2-bromomethyl-5-phenyl-1,3-oxazolidin-4-one 
• 492435-12-8 (2S,6R,7aS)-7a-(tert-butyldimethylsilyl)oxy-6-methyl-2-phenyltetrahydropyrrolo[2,1-b]oxazol-3-one 
• 259857-38-0 (S)-4-isopropyl-3-[(R)-3-methyl-4-nitrobutanoyl]-5,5-diphenyloxazolidin-2-one 

Downstream Products

• 259857-57-3 (R)-(+)-4-(tert-butoxycarbonyl)amino-3-methylbutanoic acid 
• 1116-92-3 (R)-3-methyl-4-aminobutyric acid 

Relevant articles and documents

Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes

A new synthetic approach to (3R)-4-amino-3-methylbutyric acid and [(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [(R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of dieth

The 5-exo-trig radical cyclization reaction under reductive and oxidative conditions in the synthesis of optically pure GABA derivatives

Free radical precursors 4a and 4b were synthesized and treated under reductive or oxidative conditions to obtain the corresponding optically pure pyrrolidinones 5-8, which were subsequently transformed into corresponding optically pure GABA derivatives 9-11. When reductive radical conditions (4a→7 and 8) were used, a Ph1-5 migration product 14 was obtained; presumably depending upon the specific conformation of the rotamer precursor and also 14 was found to be a kinetic product.

Stereoselective formation of optically active 2-oxy-1,3-oxazolidin-4-ones and an efficient synthesis of optically active secondary 2-pyrrolidones

Treatment of (-)-O-acyllactamides or mandelamides with TBSOTf in the presence of base gives optically active 2-oxy-1,3-oxazolidin-4-ones stereoselectively, which serve as useful precursors for the preparation of optically active secondary 2-pyrrolidones via radical cyclization and subsequent one-step removal of mandelic acid.