26038-62-0

Basic information

• Product Name: 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole
• CAS NO: 26038-62-0
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.2423
• Mol File: 26038-62-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 353°C at 760 mmHg
• Flash Point: 167.3°C
• Density: 1.07g/cm³
• Vapor Pressure: 7.5E-05mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole(26038-62-0)
• EPA Substance Registry System: 2-(2-phenylethyl)-4,5-dihydro-1H-imidazole(26038-62-0)

Safety Data

• Hazardous Substances Data: 26038-62-0(Hazardous Substances Data)

Usage

Type of chemical compound

Selective dopamine transporter ligand

Potential use

Treatment of drug addiction and neurological disorders (e.g. Parkinson's disease)

Mechanism of action

High affinity for the dopamine transporter, which regulates dopamine levels in the brain

Additional potential use

Radiotracer for imaging dopamine transporters in the brain, valuable for neuroscience research and drug development.

Upstream product

• 68175-79-1 3-phenyl-propionimidic acid methyl ester 
• 107-15-3 ethylenediamine 
• 104-53-0 3-phenyl-propionaldehyde 
• 645-59-0 dihydrocinnamonitrile 
• 272110-20-0 1-tert-butyloxycarbonyl-2-(2-phenylethyl)-2-imidazoline 

Relevant articles and documents

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.

One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates

Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphatic aldehydes and N-nonsubstituted and N-monosubstituted 1,2-diamines. Furthermore, it was found that CH2Cl2 could be altered to TBME, a more environmentally friendly solvent, in the reaction using N-nonsubstituted 1,2-diamines. The reaction conditions were very mild and chemoselective.

A new protocol for the synthesis of N(1)-unsubstituted 2-substituted 2 imidazolines

Lateral metallation at C-2(α) of 1-tert-butoxycarbonyl-2-methyl-2- imidazoline followed by reaction with a range of C-electrophiles and deprotection with TFA reliably affords N(1)-unsubstituted 2-substituted 2- imidazolines; P- or Se-electrophiles lead to 2-alkenyl-2-imidazolines via Wadsworth-Emmons or selenoxide elimination protocols. (C) 2000 Elsevier Science Ltd.