261766-29-4 Usage
Description
N-(3-PYRIDYL)-INDOMETHACIN AMIDE is an aromatic amide derivative of indomethacin, which is a potent and selective reversible inhibitor of cyclooxygenase-2 (COX-2). It possesses significant anti-inflammatory and analgesic properties due to its ability to inhibit the COX-2 enzyme, which plays a crucial role in the production of prostaglandins, leading to inflammation and pain.
Uses
Used in Pharmaceutical Industry:
N-(3-PYRIDYL)-INDOMETHACIN AMIDE is used as an anti-inflammatory and analgesic agent for its potent and selective inhibition of the COX-2 enzyme. This inhibition helps in reducing inflammation and alleviating pain, making it a valuable compound for the development of new drugs to treat various inflammatory and pain-related conditions.
Used in Research and Development:
In the field of research and development, N-(3-PYRIDYL)-INDOMETHACIN AMIDE serves as a valuable tool for studying the role of COX-2 in various biological processes and disease pathways. Its potent and selective inhibition of COX-2 allows researchers to investigate the enzyme's contribution to inflammation, pain, and other related conditions, potentially leading to the discovery of novel therapeutic targets and treatment strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, N-(3-PYRIDYL)-INDOMETHACIN AMIDE can also be incorporated into drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the compound's efficacy against specific targets, such as COX-2, can be improved, leading to more effective treatments for inflammation and pain-related conditions.
Biological Activity
n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].
references
[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.
Check Digit Verification of cas no
The CAS Registry Mumber 261766-29-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,7,6 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 261766-29:
(8*2)+(7*6)+(6*1)+(5*7)+(4*6)+(3*6)+(2*2)+(1*9)=154
154 % 10 = 4
So 261766-29-4 is a valid CAS Registry Number.
261766-29-4Relevant articles and documents
Indomethacin amides as a novel molecular scaffold for targeting trypanosoma cruzi sterol 14α-demethylase
Konkle, Mary E.,Hargrove, Tatiana Y.,Kleshchenko, Yuliya Y.,Von Kries, Jens P.,Ridenour, Whitney,Uddin, Md Jashim,Caprioli, Richard M.,Marnett, Lawrence J.,Nes, W. David,Villalta, Fernando,Waterman, Michael R.,Lepesheva, Galina I.
experimental part, p. 2846 - 2853 (2010/01/16)
Trypanosoma cruzi (TC) causes Chagas disease, which in its chronic stage remains incurable. We have shown recently that specific inhibition of TC sterol 14α-demethylase (TCCYP51) with imidazole derivatives is effective in killing both extracellular and in
