261922-46-7Relevant articles and documents
Pharmaceutical compositions based on azetidine derivatives
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, (2008/06/13)
A stable pharmaceutical composition comprising at least one azetidine derivative of formula in which Ar is an aromatic or heteroaromatic group optionally substituted with one or more (C1-C4)alkyl, halogen, NO2, CN, (C1-C4)alkoxy or OH groups, optionally in combination with one or more other active ingredients capable of potentiating the effects of the at least one azetidine derivative of formula (Ia) or (Ib), in a system comprising at most 2 principal excipients chosen from nonionic and hydrophilic surfactants capable of solubilizing the at least one azetidine derivative of formula (Ia) or (Ib) and, where appropriate, the one or more active ingredients potentiating the effects of the at least one azetidine derivative, and capable of causing the formation of a colloidal system, optionally supplemented with a second excipient of a lipophilic nature. The pharmaceutical compositions are advantageous because, for example, of the high affinity of the derivatives for cannabinoid receptors.
Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity
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, (2008/06/13)
The present invention relates to the combination of a CB1 receptor antagonist and of sibutramine, to the pharmaceutical compositions comprising them and to their use in the treatment of obesity.
