2621-46-7

Basic information

• Product Name: 4-chlorocumene
• Synonyms: 4-chlorocumene;Benzene, 1-chloro-4-(1-methylethyl)-;1-Chloro-4-isopropylbenzene;1-Isopropyl-4-chlorobenzene
• CAS NO: 2621-46-7
• Molecular Formula: C₉H₁₁Cl
• Molecular Weight: 154.63664
• EINECS: 220-061-9
• Mol File: 2621-46-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: -12.3°C
• Boiling Point: 198.35°C
• Flash Point: 314°C
• Appearance: /
• Density: 1.0324 (estimate)
• Vapor Pressure: 0.511mmHg at 25°C
• Refractive Index: 1.5117
• CAS DataBase Reference: 4-chlorocumene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorocumene(2621-46-7)
• EPA Substance Registry System: 4-chlorocumene(2621-46-7)

Safety Data

• Hazardous Substances Data: 2621-46-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11Cl/c1-7(2)8-3-5-9(10)6-4-8/h3-7H,1-2H3

Upstream product

• 98-82-8 Isopropylbenzene 
• 676-58-4 methylmagnesium chloride 
• 13940-94-8 (4-chlorophenyl)dichloromethane 
• 99-88-7 4-Isopropylaniline 
• 82146-18-7 1-chloro-2,4-diisopropylbenzene 
• 108-90-7 chlorobenzene 
• 106-46-7 para-dichlorobenzene 
• 1068-55-9 isopropylmagnesium chloride 
• 14596-60-2 N-chloro-N-(4-methylphenyl)acetamide 
• 187737-37-7 propene 
• 106-39-8 bromochlorobenzene 
• 1888-75-1 isopropyllithium 
• 75-26-3 isopropyl bromide 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 13075-05-3 1,2,3,4,5-pentabromo-6-chlorobenzene 
• 16535-03-8 2,3-Bis(4-chlorphenyl)-2,3-dimethylbutan 
• 76611-15-9 4-chloro-3-nitroisopropylbenzene 
• 93449-07-1 1-(α-bromo-isopropyl)-4-chloro-benzene 
• 108-90-7 chlorobenzene 
• 99-91-2 para-chloroacetophenone 
• 76611-16-0 1-chloro-4-isopropyl-3-nitrobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 1989-25-9 4-chlorocumyl alcohol 
• 74-11-3 para-chlorobenzoic acid 
• 3077-67-6 α.α-Dimethyl-<4-chlor-benzyl>-hydroperoxyd 
• 99-88-7 4-Isopropylaniline 
• 7116-95-2 4-isopropylbiphenyl 
• 1435393-25-1 1-isopropyl-4-(2,2-dimethoxypropyl)benzene 

Relevant articles and documents

Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes

Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.

Amine-Borane Dehydrogenation and Transfer Hydrogenation Catalyzed by α-Diimine Cobaltates

Anionic α-diimine cobalt complexes, such as [K(thf)1.5{(DippBIAN)Co(η4-cod)}] (1; Dipp=2,6-diisopropylphenyl, cod=1,5-cyclooctadiene), catalyze the dehydrogenation of several amine-boranes. Based on the excellent catalytic properties, an especially effective transfer hydrogenation protocol for challenging olefins, imines, and N-heteroarenes was developed. NH3BH3 was used as a dihydrogen surrogate, which transferred up to two equivalents of H2 per NH3BH3. Detailed spectroscopic and mechanistic studies are presented, which document the rate determination by acidic protons in the amine-borane.

Olefin-Stabilized Cobalt Nanoparticles for C=C, C=O, and C=N Hydrogenations

The development of cobalt catalysts that combine easy accessibility and high selectivity constitutes a promising approach to the replacement of noble-metal catalysts in hydrogenation reactions. This report introduces a user-friendly protocol that avoids complex ligands, hazardous reductants, special reaction conditions, and the formation of highly unstable pre-catalysts. Reduction of CoBr2 with LiEt3BH in the presence of alkenes led to the formation of hydrogenation catalysts that effected clean conversions of alkenes, carbonyls, imines, and heteroarenes at mild conditions (3 mol % cat., 2–10 bar H2, 20–80 °C). Poisoning studies and nanoparticle characterization by TEM, EDX, and DLS supported the notion of a heterotopic catalysis mechanism.