2642-63-9

Basic information

• Product Name: 3',4'-DICHLOROACETOPHENONE
• Synonyms: 1-(3,4-DICHLOROPHENYL)ETHAN-1-ONE;1-(3,4-DICHLOROPHENYL)ETHANONE;3',4'-DICHLOROACETOPHENONE;3,4-DICHLOROACETOPHENONE;AKOS BBS-00003230;1-(3,4-dichlorophenyl)-ethanon;Acetophenone, 3',4'-dichloro-;3',4'-Dichloroacetophenone 1-(3,4-Dichlorophenyl)ethanone 3,4-Dichloroacetophenone
• CAS NO: 2642-63-9
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.04
• EINECS: 220-146-0
• Product Categories: Acetophenone Series;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds;C7 to C8;Carbonyl Compounds;Ketones;Aromatics;Miscellaneous Reagents
• Mol File: 2642-63-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 72-74 °C(lit.)
• Boiling Point: 135 °C12 mm Hg(lit.)
• Flash Point: 134-135mm°C/12mm
• Appearance: white to cream-colored powder or crystals
• Density: 1.2979 (rough estimate)
• Refractive Index: 1.5595 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 742534
• CAS DataBase Reference: 3',4'-DICHLOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DICHLOROACETOPHENONE(2642-63-9)
• EPA Substance Registry System: 3',4'-DICHLOROACETOPHENONE(2642-63-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39-36-36/37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2642-63-9(Hazardous Substances Data)

Usage

Chemical Properties

white to cream-colored cryst. powder or crystals

Uses

Different sources of media describe the Uses of 2642-63-9 differently. You can refer to the following data:
1. 3'',4''-Dichloroacetophenone (cas# 2642-63-9) is a compound useful in organic synthesis.
2. 3′,4′-Dichloroacetophenone (3,4-Dichloroacetophenone) was used in the synthesis of substituted aryl aminothiazoles.

Upstream product

• 75-36-5 acetyl chloride 
• 95-50-1 1,2-dichloro-benzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 99-91-2 para-chloroacetophenone 
• 74877-07-9 1-(S)-(-)-(3,4-dichlorophenyl)-ethylamine 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 103274-64-2 acetic acid-(2-acetyl-5-chloro-anilide) 
• 113402-19-0 2-cyclopentyl-1-(3,4-dichlorophenyl)ethanone 
• 108-24-7 acetic anhydride 
• 857560-77-1 1-(2-amino-4-chloro-5-nitro-phenyl)-ethanone 
• 857560-79-3 1-(2-amino-4-chloro-3-nitro-phenyl)-ethanone 
• 1475-11-2 1-(3,4-dichlorophenyl)ethan-1-ol 
• 79406-57-8 3-amino-4-chloroacetophenone 

Downstream Products

• 1475-11-2 1-(3,4-dichlorophenyl)ethan-1-ol 
• 85660-44-2 2-(3,4-dichloro-phenyl)-but-3-yn-2-ol 
• 6623-59-2 1,2-dichloro-4-ethylbenzene 
• 139752-39-9 1-(3,4-dichlorophenyl)ethanone oxime 
• 6635-71-8 4,5-Dichloro-2-nitroacetophenone 
• 6953-83-9 1-(4-amino-3-chlorophenyl)ethan-1-one 
• 22107-28-4 1-(3,4-dichloro-phenyl)-ethanone semicarbazone 
• 2632-10-2 2-bromo-1-(3,4-dichlorophenyl)ethanone 
• 19271-23-9 3-Cyclopropylamino-3',4'-dichlorpropiophenon 
• 114727-47-8 3-(3,4-dichloro-α-methylbenzylidene)-oxindole 
• 80827-33-4 1,3-Bis(3,4-dichlorophenyl)pyrido<1,2-a>benzinidazole 
• 148887-62-1 2-(3,4-Dichloro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid 
• 101065-90-1 1-(3,4-Dichloro-phenyl)-4,4,4-trifluoro-3-trifluoromethyl-butane-1,3-diol 
• 75144-12-6 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride 

Relevant articles and documents

Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

V2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls

The versatile application of different functional groups such as alcohols (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, we report a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions. The method was successfully applied for the alcohol oxidation, oxidative scission of styrenes, and benzylic C?H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30 % aq.), TBHP (70 % aq.), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol.

Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators

Antibiotic resistance among clinically significant bacterial pathogens is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. Utilizing computational docking method and structure-based optimization strategy, we rationally designed and synthesized two series of isoxazol-3-yl- and isoxazol-5-yl-containing benzamide derivatives that targeted the bacterial cell division protein FtsZ. Evaluation of their activity against a panel of Gram-positive and -negative pathogens revealed that compounds B14 and B16 that possessed the isoxazol-5-yl group showed strong antibacterial activity against various testing strains, including methicillin-resistant Staphylococcus aureus and penicillin-resistant S. aureus. Further molecular biological studies and docking analyses proved that the compound functioned as an effective inhibitor to alter the dynamics of FtsZ self-polymerization via a stimulatory mechanism, which finally terminated the cell division and caused cell death. Taken together, these results could suggest a promising chemotype for development of new FtsZ-targeting bactericidal agent.