26510-52-1

Basic information

• Product Name: ETHYL PICOLINOYLACETATE
• Synonyms: Ethyl picolinoylacetate, Ethyl 3-oxo-3-(pyridin-2-yl)propionate, 2-(3-Ethoxy-3-oxopropanoyl)pyridine;Ethyl picolinoylacetate, 95% 2.5GR;Ethyl 3-oxo-3-(2-pyridyl)propionate, 95+%;Ethyl 3-(2-pyridyl)-3-oxopropionate;2-Pyridinepropanoic acid, β-oxo-, ethyl ester;Ethyl 3-oxo-3-(pyridin-2-yl);ETHYL PICOLINOYLACETATE;ETHYL 3-OXO-3-(2-PYRIDYL)PROPIONATE
• CAS NO: 26510-52-1
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 26510-52-1.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 100-104 °C (0.3 mmHg)
• Flash Point: 121℃
• Appearance: Clear straw-yellow to brown/Liquid
• Density: 1.164
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.516-1.519
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.37±0.46(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: ETHYL PICOLINOYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL PICOLINOYLACETATE(26510-52-1)
• EPA Substance Registry System: ETHYL PICOLINOYLACETATE(26510-52-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-22-26
• Hazardous Substances Data: 26510-52-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear straw-yellow to brown liquid

InChI:InChI=1/C10H11NO3/c1-2-14-10(13)7-9(12)8-5-3-4-6-11-8/h3-6H,2,7H2,1H3

Upstream product

• 2524-52-9 ethyl-2-picolinate 
• 141-78-6 ethyl acetate 
• 1122-62-9 2-acetylpyridine 
• 105-58-8 Diethyl carbonate 
• 1121-60-4 pyridine-2-carbaldehyde 
• 100-70-9 2-Cyanopyridine 
• 105-36-2 ethyl bromoacetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 109-04-6 2-bromo-pyridine 
• 6148-64-7 ethyl potassium malonate 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 100312-28-5 imidazol-1-yl-pyridin-2-yl-methanone 
• 98-98-6 2-Picolinic acid 
• 2459-07-6 methyl pyridine-2-carboxylate 

Downstream Products

• 40086-66-6 2-Bromoacetylpyridine 
• 1122-62-9 2-acetylpyridine 
• 2706-56-1 2-(aminoethyl)pyridine 
• 75140-33-9 2-amino-1-[2]pyridyl-ethanone 
• 947271-61-6 1-phenyl-5-(pyridin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid 
• 20364-46-9 4-phenyl-2-(2'-pyridinyl)quinoline 

Relevant articles and documents

Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agents

Hepatitis B virus (HBV) is an infectious disease, which can cause acute and chronic infections. Every year, over 7.5 million persons die due to HBV. No effective drug exists for the treatment of HBV. Thus, we designed and synthesized 16 new pyridine-pyraz

Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.