265331-11-1

Basic information

• Product Name: N⁴-benzoyl-1-{2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(dimethoxytrityl)-3-α-[N-(5'-deoxythymidin-5'-yl)carboxamido]methyl-β-D-ribofuranosyl}cytosine
• Synonyms: N⁴-benzoyl-1-{2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(dimethoxytrityl)-3-α-[N-(5'-deoxythymidin-5'-yl)carboxamido]methyl-β-D-ribofuranosyl}cytosine
• CAS NO: 265331-11-1
• Molecular Weight: 1029.23
• Mol File: 265331-11-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁴-benzoyl-1-{2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(dimethoxytrityl)-3-α-[N-(5'-deoxythymidin-5'-yl)carboxamido]methyl-β-D-ribofuranosyl}cytosine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴-benzoyl-1-{2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(dimethoxytrityl)-3-α-[N-(5'-deoxythymidin-5'-yl)carboxamido]methyl-β-D-ribofuranosyl}cytosine(265331-11-1)
• EPA Substance Registry System: N⁴-benzoyl-1-{2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(dimethoxytrityl)-3-α-[N-(5'-deoxythymidin-5'-yl)carboxamido]methyl-β-D-ribofuranosyl}cytosine(265331-11-1)

Safety Data

• Hazardous Substances Data: 265331-11-1(Hazardous Substances Data)

Upstream product

• 25152-20-9 5'-amino-5'-deoxythymidine 
• 265331-10-0 N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-α-(carboxy)methyl-3-deoxy-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine 
• 90813-54-0 2',5'-bis-O-tert-butyldimethylsilyl-3'-ketouridine 
• 251296-54-5 1-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-(ethoxycarbonyl)methylene-β-D-ribofuranosyl]uracil 
• 178985-82-5 1-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-α-(ethoxycarbonyl)methyl-β-D-ribofuranosyl]uracil 
• 265331-08-6 N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-3-α-(ethoxycarbonyl)methyl-β-D-ribofuranosyl]cytosine 
• 265331-06-4 1-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-α-(ethoxycarbonyl)methyl-β-D-ribofuranosyl]-1,2-dihydro-4-(1-triazolyl)pyrimidin-2-one 
• 265331-09-7 N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-deoxy-3-α-(ethoxycarbonyl)methyl-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine 
• 265331-07-5 N⁴-benzoyl-1-[2,5-bis-O-(tert-butyldimethylsilyl)-3-deoxy-3-α-(ethoxycarbonyl)methyl-β-D-ribofuranosyl]cytosine 

Relevant articles and documents

Replacement of the cleavable phosphodiester bond of a hammerhead ribozyme substrate by an amide linkage

A nucleoside dimer in which the natural phosphodiester bond is replaced by an isosteric amide linkage has been prepared. This dimer analogue was subsequently incorporated chemically at the cleavage position of a hammerhead ribozyme substrate. Although the resulting substrate analogue exhibited a high affinity for the ribozyme as shown by gel retardation assays, the amide bond proved to be fully resistant to cleavage under standard conditions of ribozyme cleavage activity.