26553-34-4 Usage
General Description
The chemical compound (R)-phenyl[[(2,2,2-trichloroethoxy)carbonyl]amino]acetic acid is a crystalline powder substance that is used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is an amino acid derivative with a phenyl group and a trichloroethoxy carbonyl group attached to the amino and carboxylic acid functional groups, respectively. (R)-phenyl[[(2,2,2-trichloroethoxy)carbonyl]amino]acetic acid has potential applications in drug discovery and development due to its ability to act as a prodrug, as well as its ability to modulate biological activity through interactions with target proteins. Additionally, it has shown promising results in the treatment of certain diseases and disorders. However, further research and clinical trials are needed to fully understand its potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 26553-34-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,5,5 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 26553-34:
(7*2)+(6*6)+(5*5)+(4*5)+(3*3)+(2*3)+(1*4)=114
114 % 10 = 4
So 26553-34-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10Cl3NO4/c12-11(13,14)6-19-10(18)15-8(9(16)17)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,15,18)(H,16,17)/t8-/m1/s1
26553-34-4Relevant articles and documents
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids
Ye, Chen-Xi,Shen, Xiang,Chen, Shuming,Meggers, Eric
, p. 566 - 573 (2022/04/07)
α-Amino acids are essential for life as building blocks of proteins and components of diverse natural molecules. In both industry and academia, the incorporation of unnatural amino acids is often desirable for modulating chemical, physical and pharmaceutical properties. Here we report a protocol for the economical and practical synthesis of optically active α-amino acids based on an unprecedented stereocontrolled 1,3-nitrogen shift. Our method employs abundant and easily accessible carboxylic acids as starting materials, which are first connected to a nitrogenation reagent, followed by a highly regio- and enantioselective ruthenium- or iron-catalysed C(sp3)–H amination. This straightforward method displays a very broad scope, providing rapid access to optically active α-amino acids with aryl, allyl, propargyl and alkyl side chains, and also permits stereocontrolled late-stage amination of carboxylic-acid-containing drugs and natural products. [Figure not available: see fulltext.]
