265644-03-9

Basic information

• Product Name: 2,5-difluorobenzohydrazide
• Synonyms: 2,5-difluorobenzohydrazide;Benzoic acid, 2,5-difluoro-, hydrazide
• CAS NO: 265644-03-9
• Molecular Formula: C₇H₆F₂N₂O
• Molecular Weight: 172.1321464
• Mol File: 265644-03-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-difluorobenzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-difluorobenzohydrazide(265644-03-9)
• EPA Substance Registry System: 2,5-difluorobenzohydrazide(265644-03-9)

Safety Data

• Hazardous Substances Data: 265644-03-9(Hazardous Substances Data)

Usage

General Description

2,5-difluorobenzohydrazide is a chemical compound with the molecular formula C7H5F2N3O. It is a white to creamy powder with a molecular weight of 177.13 g/mol. 2,5-difluorobenzohydrazide is often used in the synthesis of pharmaceutical drugs and agrochemicals due to its versatile reactivity and ability to form various derivatives. It possesses two fluorine atoms attached to the benzene ring, which can enhance the compound's biological activity and make it a valuable building block in drug design and development. Additionally, 2,5-difluorobenzohydrazide has also shown potential as a corrosion inhibitor and in the field of materials science. Overall, this compound has diverse applications and is a valuable tool in chemical synthesis and research.

Upstream product

• 1079843-62-1 C₁₂H₁₄F₂N₂O₃ 
• 708-25-8 ethyl 2,5-difluorobenzoate 
• 2991-28-8 2,5-difluorobenzoic acid 

Downstream Products

• 1243273-14-4 3-(2,5-difluorophenyl)-6-(1H-indol-5-yl)-1,2,4-triazalo[4,3-b]pyridazine 
• 1459280-41-1 (E)-N’-(3-(trifluoromethyl)benzylidene)-2,5-difluorobenzohydrazide 
• 1459280-42-2 (E)-N’-(4-(trifluoromethyl)benzylidene)-2,5-difluorobenzohydrazide 
• 1459280-43-3 (E)-N’-(4-(trifluoromethoxy)benzylidene)-2,5-difluorobenzohydrazide 
• 1459280-45-5 (E)-N’-(2,4-difluorobenzylidene)-2,5-difluorobenzohydrazide 
• 1459280-46-6 (E)-N’-(2,4-dimethoxybenzylidene)-2,5-difluorobenzohydrazide 
• 1459280-47-7 (E)-N’-(2,5-dimethoxybenzylidene)-2,5-difluorobenzohydrazide 
• 1459280-48-8 (E)-N’-(3,4,5-trimethoxybenzylidene)-2,5-difluorobenzohydrazide 
• 800406-59-1 (E)-N'-(benzofuran-2-yl)methylene-2,5-difluorobenzohydrazide 
• 1459280-38-6 (E)-N'-(benzylidene)-2,5-difluorobenzohydrazide 
• 1459280-39-7 (E)-N'-(4-fluorobenzylidene)-2,5-difluorobenzohydrazide 
• 1459280-40-0 (E)-N'-(4-bromobenzylidene)-2,5-difluorobenzohydrazide 
• 367281-18-3 3-tert-butyl-7-(2,5-difluorophenyl)-2-(2-ethyl-2H-[1,2,4]triazol-3-ylmethoxy)-4-methylpyrazolo[1,5-d][1,2,4]triazine 

Relevant articles and documents

Synthesis and anti-inflammatory activity of hydrazide-hydrazones bearing anacardic acid and 1,2,3-triazole ring based hybrids

A novel series of hydrazide-hydrazone derivatives 39-50, linked with anacardic acid motif and 1,2,3-triazole ring were synthesized by reacting 4-(1-(2-methoxy-6-pentadecylbenzyl)-1H-1, 2, 3-triazol-4-yl)benzaldehyde with 2-phenyl-acetohydrazides and benzohydrazides. The structures of the newly synthesized hydrazide-hydrazone derivatives 39-50 were confirmed by 1H NMR, MS and IR spectroscopic tools. These compounds were also evaluated for their anti-inflammatory activity by carrageenan paw edema method.

Synthesis, characterization and antimicrobial evaluation of novel (E)-N′-(4-(1-((3,4-dimethoxypyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)benzylidene)benzohydrazide derivatives

The synthesis of novel 1,2,3-triazole-hydrazone derivatives embedded with 3,4-dimethoxy pyridine ring nucleus is described. These derivatives were prepared utilizing, 2-(chloromethyl)-3,4-dimethoxypyridine 1, 4-ethynylbenzaldehye 5 and various benzohydrazides7a-7j. The structures of the newly synthesized 1,2,3-triazole-hydrazones 8a-j was established on the basis of the spectroscopic techniques like 1H NMR, mass and IR data. They were evaluated against a panel of bacterial and fungal pathogens such as Staphylococcus. pyogens, Staphylococcus. Aureus (Gram positive bacteria), Escherichia.coli, Pseudomonas. aeruginosa (Gram negative bacteria) and Aspergillus niger and Candida albicans (Fungal stains). Compounds 8b, 8c, 8d, 8e and 8f with R = 4-OH, 4-OMe, 4-SO2Me, 3,45,-OMe and 3-NO2 respectively showed moderate antibacterial activity while compounds 8b, 8d, 8i and 8j with R = 4-OH, 4-SO2Me, 3,5-dichloro and 2,5-difluoro substitution exhibited very good fungal activity.

Synthesis and antimicrobial activity of new imidazole-hydrazone derivatives

Hydrazones demonstrated significant antimicrobial activity, antitubercular activity and antitumoral activity in medicinal areas. The imidazole nucleus is well known to play an important role in living organisms since it is incorporated into the histidine molecule and many other important biological, pharmacological and therapeutic activities. Condensation of 4-phenyl-1H-imidazole-2-carbaldehyde (3) with various selected benzohydrazides (4a-m) resulted in imidazole-hydrazone derivatives (5a-m). They were evaluated for antibacterial and antifungal activity against A. Niger, C. albicans (fungal strains), E. coli and P. aeruginosa (Gram-negative bacteria), S. aureus and S. pyogenes (Gram-positive bacteria) using griseofluvin (for fungi) and ciprofloxacin (for bacteria) as the standard drugs. In general, it is observed that most of the compounds were found to be potent against both the bacterial and fungal strains.