265998-03-6

Basic information

• Product Name: {2-[1-(3,4-dichloro-phenyl)-1-iodomethyl-3-trityloxy-propoxy]-ethyl}-carbamic acid tert-butyl ester
• Synonyms: {2-[1-(3,4-dichloro-phenyl)-1-iodomethyl-3-trityloxy-propoxy]-ethyl}-carbamic acid tert-butyl ester
• CAS NO: 265998-03-6
• Molecular Weight: 746.513
• Mol File: 265998-03-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: {2-[1-(3,4-dichloro-phenyl)-1-iodomethyl-3-trityloxy-propoxy]-ethyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {2-[1-(3,4-dichloro-phenyl)-1-iodomethyl-3-trityloxy-propoxy]-ethyl}-carbamic acid tert-butyl ester(265998-03-6)
• EPA Substance Registry System: {2-[1-(3,4-dichloro-phenyl)-1-iodomethyl-3-trityloxy-propoxy]-ethyl}-carbamic acid tert-butyl ester(265998-03-6)

Safety Data

• Hazardous Substances Data: 265998-03-6(Hazardous Substances Data)

Upstream product

• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 

Downstream Products

• 191673-56-0 (R)-2-(2-(3,4-dichlorophenyl)morpholin-2-yl)ethanol 
• 181640-70-0 2-(3,4-Dichlorophenyl)-2-(2-hydroxyethyl)morpholine 
• 265998-02-5 2-(3,4-dichloro-phenyl)-2-(2-trityloxy-ethyl)-morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

A versatile method for the preparation of 2,2-disubstituted morpholine analogues

We describe a versatile synthetic method for the preparation of 2,2- disubstituted morpholine analogues. Iodo-etherification of 1,1-disubstituted olefin with N-Boc-aminoethanol using NIS proceeded smoothly in a regioselective manner and the following cyclization was accomplished in good yield. We successfully applied this method for the preparation of the key intermediate 2 of tachykinin receptor antagonist. (C) 2000 Elsevier Science Ltd.