26673-31-4

Basic information

• Product Name: 6-Chloro-1-tetralone
• Synonyms: 6-CHLORO-TETRAL-1-ON;6-Chloro-1-tetralone;6-Chloro-α-Tetralone;5-CHLORO-L-INDOMONE;6-Chloro-tetral-1-one;6-Chloro-3,4-dihydro-2H-naphthalen-1-one;5-CHLORO-1-INDOMONE;3,4,6-trichloronaphthalen-1(2H)-one
• CAS NO: 26673-31-4
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63
• EINECS: 1533716-785-6
• Mol File: 26673-31-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 53 °C
• Boiling Point: 150°C/0.7mmHg(lit.)
• Flash Point: 146.727 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Chloro-1-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-1-tetralone(26673-31-4)
• EPA Substance Registry System: 6-Chloro-1-tetralone(26673-31-4)

Safety Data

• Hazardous Substances Data: 26673-31-4(Hazardous Substances Data)

Usage

Uses

6-Chloro-1-tetralone is a novel and potent intermediate used for synthesis of pharmaceutical compounds.

Synthesis

A solution of sodium nitrite (173 mg, 2.51 mmol) in water (5 mL) at 0 °C (ice-bath) was added to a magnetically stirred suspension of 6-Amino-1-tetralone (360 mg, 2.23 mmol) in aqueous hydrochloric acid (10 mL, 6 M) at 0 °C. This reaction mixture was added dropwise to a solution of copper(I) chloride (267 mg, 2.70 mmol) in concentrated hydrochloric acid (5 mL) at 0 °C. It was allowed to warm up to room 100 temperature and stirred for a further 2 h after which it was neutralised with solid sodium carbonate, extracted with ethyl acetate (3 × 20 mL) and concentrated in vacuo to give slightly yellow oil. This material was subjected to flash chromatography (50% chloroform in hexane) and concentration of the appropriate fractions afforded 6-chloro-1-tetralone (180 mg, 45%) as a waxy solid.

InChI:InChI=1/C10H9ClO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6H,1-3H2

Upstream product

• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 75693-16-2 6-chloro-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 17556-18-2 6-chloro-3,4-dihydro-1H-naphthalen-2-one 
• 36978-49-1 4-(4-chlorobenzoyl)butanoic acid 
• 1355061-67-4 ethyl 4-(3-chlorophenyl)butanoate 
• 29480-09-9 1-(4-chlorophenyl)cyclobutan-1-ol 
• 144464-64-2 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate 
• 517874-22-5 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-one 
• 3470-53-9 6-amino-1-tetralone 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 418761-92-9 2-hydroxy-2-methyl-N-(5-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)propanamide 
• 418761-91-8 2-methyl-2-[(5-oxo-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]propanamide 
• 22991-05-5 4-(3-chlorophenyl)-butyric acid 
• 24344-58-9 tributyl(3-chlorophenyl)stannane 

Downstream Products

• 149455-83-4 6-chloro-2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one 
• 852409-38-2 ethyl α-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-α-oxoacetate 
• 54714-42-0 2-bromo-6-chloro-α-tetralone 
• 22246-70-4 7-chloro-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 
• 1350662-97-3 ethyl 6-chloro-1-hydroxy-2-naphthoate 
• 1463609-33-7 1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole 
• 1463609-35-9 2H-1-aza-2-oxa-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[1,2-c]isoxazole 
• 1463609-22-4 tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate 
• 1568990-34-0 tert-butyl 6-chloro-1-tetralone-2-carboxylate 
• 1617525-22-0 C₂₁H₁₆BrClO₂ 
• 56820-70-3 2-chloro-5-hydroxynaphthalene 

Relevant articles and documents

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