267400-83-9 Usage
Description
3-HYDROXY-2-(5-HYDROXYPENTYL)CHROMEN-4-ONE is a chemical compound characterized as a colorless solid. It is an iron tridentate chelator that plays a crucial role in inactivating the iron redox cycle after complexation.
Uses
Used in Chemical Industry:
3-HYDROXY-2-(5-HYDROXYPENTYL)CHROMEN-4-ONE is used as an iron tridentate chelator for inactivating the iron redox cycle after complexation. This application is particularly important in the chemical industry where controlling redox reactions is crucial for various processes and preventing unwanted side reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-HYDROXY-2-(5-HYDROXYPENTYL)CHROMEN-4-ONE is used as a potential therapeutic agent for conditions related to iron overload or redox imbalances. Its ability to chelate iron and inactivate the iron redox cycle can help mitigate the harmful effects of excess iron and oxidative stress in the body.
Used in Research and Development:
3-HYDROXY-2-(5-HYDROXYPENTYL)CHROMEN-4-ONE is also utilized in research and development settings for studying the role of iron in various biological processes and diseases. Its unique properties as an iron tridentate chelator make it a valuable tool for investigating the mechanisms of iron-related redox reactions and their implications in health and disease.
Check Digit Verification of cas no
The CAS Registry Mumber 267400-83-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,7,4,0 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 267400-83:
(8*2)+(7*6)+(6*7)+(5*4)+(4*0)+(3*0)+(2*8)+(1*3)=139
139 % 10 = 9
So 267400-83-9 is a valid CAS Registry Number.
267400-83-9Relevant articles and documents
Design, synthesis, and physicochemical and biological characterization of a new iron chelator of the family of hydroxychromenes
Ferrali, Marco,Bambagioni, Sabrina,Ceccanti, Antonio,Donati, Donato,Giorgi, Giancola,Fontani, Marco,Laschi, Franco,Zanello, Piero,Casolaro, Mario,Pietrangelou, Antonello
, p. 5776 - 5785 (2002)
Increasing evidence suggests that iron plays an important role in tissue damage both during chronic iron overload diseases (i.e., hemochromatosis) and when, in the absence of actual tissue iron overload, iron is delocalized from specific carriers or intracellular sites (inflammation, neurodegenerative diseases, postischaemic reperfusion, xenobiotic intoxications, etc.). In the present work, we appropriately modified an iron chelator of the hydroxychromene family in order to obtain a tridentate chelator that would inactivate the iron redox cycle after its complexation, with a view to using this molecule in human therapy and/or in disease prevention. We synthesized such a chelator for the first time and show, by different physicochemical analysis, its tridentate nature and, importantly, its capacity to chelate iron with enough strength to inhibit both iron-dependent H2O2 generation and lipid peroxidation in in vitro biological systems.
