267413-25-2

Basic information

• Product Name: 5-AMINOMETHYL INDAZOLE
• Synonyms: C-(1H-Indazol-5-yl)-methylamine;(1H-Indazol-5-yl);5-AMINOMETHYL INDAZOLE;5-Aminomethyl-1H-indazole;(1H-indazol-5-yl)methanamine;1H-Indazole-5-methanamine;1-(1H-indazol-5-yl)methanamine
• CAS NO: 267413-25-2
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Product Categories: Building Blocks;Indazole
• Mol File: 267413-25-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 352.1 °C at 760 mmHg
• Flash Point: 193.8 °C
• Appearance: /
• Density: 1.279 g/cm³
• Vapor Pressure: 3.93E-05mmHg at 25°C
• Refractive Index: 1.712
• PKA: 14.10±0.40(Predicted)
• CAS DataBase Reference: 5-AMINOMETHYL INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINOMETHYL INDAZOLE(267413-25-2)
• EPA Substance Registry System: 5-AMINOMETHYL INDAZOLE(267413-25-2)

Safety Data

• Hazardous Substances Data: 267413-25-2(Hazardous Substances Data)

Usage

General Description

5-Aminomethyl indazole is a chemical compound that belongs to the class of indazole derivatives. It is a white powder that is used in various chemical and pharmaceutical applications. 5-Aminomethyl indazole has been studied for its potential role in drug development, particularly in the field of pharmacology and medicinal chemistry. It is known for its ability to act as a building block in the synthesis of various bioactive molecules and pharmaceutical drugs. Additionally, research has shown that 5-aminomethyl indazole exhibits antimicrobial and antitumor activities, making it a potential candidate for the development of new drugs to treat infectious and cancerous diseases.

InChI:InChI=1/C8H9N3/c9-4-6-1-2-8-7(3-6)5-10-11-8/h1-3,5H,4,9H2,(H,10,11)

Upstream product

• 74626-47-4 1H-indazole-5-carbonitrile 

Downstream Products

• 1612182-02-1 6-(2,3-dimethylphenyl)-4-N-(1H-indazol-5-ylmethyl)pyrimidine-2,4-diamine 

Relevant articles and documents

FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to fused heterocyclic compounds of formula (I): which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schi

Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway

We report the synthesis and biological evaluation of N-[(1-aryl-1H-indazol-5-yl)methyl]amide derivatives as Smoothened antagonists and inhibitors of the Hedgehog pathway. Identification of the lead structure 1 by HTS, followed by SAR study on the amide and aryl portions led to the discovery of antagonists with nanomolar activity.

PYRAZOLOPYRIMIDINES AS CYCLIN-DEPENDENT KINASE INHIBITORS

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.