267875-65-0

Basic information

• Product Name: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL
• Synonyms: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL;2,2-Difluoro-2-(2-pyridyl)ethan-1-ol;2,2-Difluoro-2-(pyridin-2...;2-Pyridineethanol, b,b-difluoro-;2,2-Difluoro-2-(2-pyridyl)ethanol
• CAS NO: 267875-65-0
• Molecular Formula: C₇H₇F₂NO
• Molecular Weight: 159.1333864
• Mol File: 267875-65-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 255℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.275
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.478
• PKA: 13.31±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(267875-65-0)
• EPA Substance Registry System: 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL(267875-65-0)

Safety Data

• Hazardous Substances Data: 267875-65-0(Hazardous Substances Data)

Usage

General Description

2,2-Difluoro-2-pyridin-2-ylethanol is a chemical compound with the molecular formula C7H7F2NO. It is a white crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. 2,2-DIFLUORO-2-PYRIDIN-2-YLETHANOL is known for its strong fluorine substituent, which makes it useful in organic synthesis as a source of fluorine atoms for introducing fluorine atoms into other molecules. It also serves as a building block for the production of fluorine-containing pesticides and pharmaceuticals. Additionally, 2,2-Difluoro-2-pyridin-2-ylethanol is used as a solvent in chemical reactions and as a reagent in various organic transformations.

InChI:InChI=1/C7H7F2NO/c8-7(9,5-11)6-3-1-2-4-10-6/h1-4,11H,5H2

Upstream product

• 267876-28-8 ethyl 2,2-difluoro-2-(pyridin-2-yl)acetate 
• 55104-63-7 ethyl 2-(pyridin-2-yl)-2-oxoacetate 
• 109-04-6 2-bromo-pyridine 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 

Downstream Products

• 267875-68-3 2.2-Difluoro-2-(pyridin-2-yl)ethylamine 
• 1299945-50-8 2,2-difluoro-2-pyridin-2-ylethyl 4-methylbenzenesulfonate 
• 435345-04-3 2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt 

Relevant articles and documents

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

Recent efforts in the field of thrombin inhibitor research have focused on the identification of compounds with good oral bioavailability and pharmacokinetics. In this manuscript we describe a metabolism-based approach to the optimization of the 3-(2-phen

PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula I: [INSERT CHEMICAL FORMULA HERE] wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula I, and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.