2682-20-4 Usage
Description
Different sources of media describe the Description of 2682-20-4 differently. You can refer to the following data:
1. Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of? isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.
2. Methylisothiazolinone (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.
Uses
Different sources of media describe the Uses of 2682-20-4 differently. You can refer to the following data:
1. Methylisothiazolinone, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.
2. 2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c
ontaining solution.
3. Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.
Safety
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.
References
[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf
Chemical Properties
Methylisothiazolinone (MIT) is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. MIT is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.
Definition
ChEBI: Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM). It has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.
Contact allergens
MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.
Check Digit Verification of cas no
The CAS Registry Mumber 2682-20-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,8 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2682-20:
(6*2)+(5*6)+(4*8)+(3*2)+(2*2)+(1*0)=84
84 % 10 = 4
So 2682-20-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3
2682-20-4Relevant articles and documents
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Chan,A.W.K. et al.
, p. 2497 - 2506 (1970)
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Preparation method of 2-methyl-4-isothiazoline-3-one aqueous solution
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Paragraph 0045-0047, (2020/12/31)
The invention provides a preparation method of a 2-methyl-4-isothiazoline-3-one aqueous solution. The method comprises the following concrete steps: uniformly mixing N,N'-dimethyl-3,3'-dithiodipropionamide or N-methyl-3-mercaptopropionamide with a solvent; adding a halogenating agent into the mixed solution, and carrying out a halogenation ring closing reaction; filtering to obtain a product, washing a filter cake with ethyl acetate, and drying to obtain a 2-methyl-4-isothiazoline-3-one hydrochloride solid; and dissolving the 2-methyl-4-isothiazoline-3-one hydrochloride solid by using a sodiumcarbonate aqueous solution to obtain an aqueous solution of which the pH value is 5.0-7.0 and the mass fraction of 2-methyl-4-isothiazoline-3-one is 50%. According to the invention, the purity of the2-methyl-4-isothiazoline-3-one obtained by the method reaches 99.9% or above, and the content of 5-chlorine-2-methyl-4-isothiazoline-3-one can be controlled to be 100 ppm or below.
Preparation method of high-purity 2-alkyl-4-isothiazoline-3-ketone
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Paragraph 0037; 0038; 0039; 0040, (2017/07/19)
The invention discloses a preparation method of high-purity 2-alkyl-4-isothiazoline-3-ketone. The preparation method comprises the following steps: suspending amide into a reaction medium inert solvent; introducing CMI and MIT mixture tail gas or MIT tail gas generated by the previous step, so as to obtain an amide suspending solution with proper hydrogen chloride content; and introducing a chlorinating reagent. According to the preparation method, a byproduct, namely hydrogen chloride, has an inhibition effect on the generation of 5-chloro-2-alkyl-4-isothiazoline-3-ketone. The content of the hydrogen chloride is increased through utilizing reaction raw materials and solvents; and finally, the high-purity 2-alkyl-4-isothiazoline-3-ketone is obtained.
