2682-33-9

Basic information

• Product Name: N-ethyl-propiolamide
• Synonyms: N-ethyl-propiolamide;N-Ethyl-2-propynamide;PropynethylaMide;2-PropynaMide,N-ethyl-
• CAS NO: 2682-33-9
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.11518
• Mol File: 2682-33-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 74-76 °C
• Appearance: /
• Density: 0.963
• PKA: 12.91±0.46(Predicted)
• CAS DataBase Reference: N-ethyl-propiolamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-propiolamide(2682-33-9)
• EPA Substance Registry System: N-ethyl-propiolamide(2682-33-9)

Safety Data

• Hazardous Substances Data: 2682-33-9(Hazardous Substances Data)

Usage

General Description

N-ethyl-propiolamide, also known as NEPA, is a chemical compound with the molecular formula C5H9NO. It is a colorless liquid with a pungent odor, and is commonly used as a solvent and in organic synthesis. NEPA is a derivative of propiolic acid, and is classified as an amide due to the presence of the amide functional group. It has a variety of applications in industries such as pharmaceuticals, agrochemicals, and coatings. NEPA can also be used as an intermediate for the synthesis of other organic compounds, and it is important to handle and store it with proper safety precautions due to its toxic and flammable nature.

Upstream product

• 75-04-7 ethylamine 
• 623-47-2 propynoic acid ethyl ester 
• 922-67-8 propynoic acid methyl ester 

Relevant articles and documents

Alkynylboration Reaction Leading to Boron-Containing π-Extended cis-Stilbenes as a Highly Tunable Fluorophore

An unprecedented boron-containing fluorophore, π-extended cis-stilbene, obtained via alkynylboration reaction of alkynamide is reported. Boron-containing π-extended cis-stilbenes emit fluorescence with high quantum yields in the solid state and exhibit aggregation-induced emission enhancement. The broad substrate scope of the alkynylboration reaction offers facile access to electronically diverse structures, enabling fine-tuning of light absorption/emission characteristics. The boron-containing π-extended cis-stilbene with a diphenylamino group displays solvatofluorochromism via an intramolecular charge-transfer transition.

PROCESS FOR PREPARING N-H OR N-ALKYL 2-PROPYNAMIDE

Disclosed is a method for the synthesis of N-H or N-alkyl 2-propynamides useful as intermediate in the manufacture of pharmaceutically active ingredients.