269055-40-5

Basic information

• Product Name: 4-[[5-bromo-4-chloro-6-[(4-cyano-2,6-dimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile
• Synonyms: 4-[[5-bromo-4-chloro-6-[(4-cyano-2,6-dimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile
• CAS NO: 269055-40-5
• Molecular Weight: 453.728
• Mol File: 269055-40-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[[5-bromo-4-chloro-6-[(4-cyano-2,6-dimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[5-bromo-4-chloro-6-[(4-cyano-2,6-dimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile(269055-40-5)
• EPA Substance Registry System: 4-[[5-bromo-4-chloro-6-[(4-cyano-2,6-dimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile(269055-40-5)

Safety Data

• Hazardous Substances Data: 269055-40-5(Hazardous Substances Data)

Upstream product

• 114820-10-9 2,6-dimethyl-4-aminobenzonitrile 
• 269055-75-6 4-[[(5-bromo-4,6-dichloro)-2-pyrimidinyl]amino]benzonitrile 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Relevant articles and documents

PRODRUGS OF HIV REPLICATION INHIBITING PYRIMIDINES

The present invention concerns compounds of formula (A1)(A2)N—R1 (I), the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula

Prodrugs of hiv replication inhibiting pyrimidines

The present invention concerns compounds of formula (A1)(A2)N—R1 (I),the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(=O)—R8; —S(=O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula 1