269396-56-7 Usage
General Description
BOC-(R)-3-AMINO-4-(3,4-DICHLORO-PHENYL)-BUTYRIC ACID is a compound that consists of a BOC-protected (R)-3-amino-4-(3,4-dichloro-phenyl)-butyric acid. BOC-(R)-3-AMINO-4-(3,4-DICHLORO-PHENYL)-BUTYRIC ACID is commonly used in chemical and pharmaceutical research as a building block for the synthesis of various compounds, including pharmaceuticals. It is a versatile and important chemical with potential applications in drug development and medicinal chemistry. Its molecular structure and properties make it a valuable tool in the discovery and development of new medications. Additionally, its functional groups and stereochemistry offer potential for manipulation and modification in further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-56-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 269396-56:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*5)+(1*6)=197
197 % 10 = 7
So 269396-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H19Cl2NO4/c1-15(2,3)22-14(21)18-10(8-13(19)20)6-9-4-5-11(16)12(17)7-9/h4-5,7,10H,6,8H2,1-3H3,(H,18,21)(H,19,20)/t10-/m1/s1
269396-56-7Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).