2700-47-2Relevant articles and documents
Jacques et al.
, p. 150,161 (1960)
Synthesis method of D,L-naproxen
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Paragraph 0047-0050, (2019/10/01)
The invention provides a synthesis method of D,L-naproxen. The synthesis method is characterized by comprising the step of removing bromine: taking D,L-2-(5-bromo-6-methoxyl-naphthyl)-sodium propionate as a raw material, and taking water and dioxane as solvents, adding a catalyst under alkaline conditions and nitrogen protection, reacting under 80-90 DEG C, filtering after the reaction is completed, and regulating the pH (Potential of hydrogen) of filtrate by acid to obtain a final product, wherein the catalyst is one of tetrakis(triphenylphosphine)palladium or diacetatobis(triphenylphosphine)palladium(II) or palladium chloride taking triphenylphosphine as a ligand. According to the synthesis method, through optimizing the synthesis method of naproxen, the tetrakis(triphenylphosphine)palladium and the diacetatobis(triphenylphosphine) palladium(II) as well as the palladium chloride taking the triphenylphosphine as the ligand are adopted as the catalyst to remove the bromine on a benzene ring; hydrogenation and high pressure are not needed; the reaction is safe and reliable; the yield is high; the synthesis method is suitable for industrial production.
Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents
Malmedy, Florence,Wirth, Thomas
supporting information, p. 16072 - 16077 (2016/10/30)
The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.
