27060-91-9

Basic information

• Product Name: Flutazolam
• Synonyms: Flutazolam;Coreminal;MS 4101;Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-;Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)- (8CI);Ro 7-6102;10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one;10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
• CAS NO: 27060-91-9
• Molecular Formula: C₁₉H₁₈ClFN₂O₃
• Molecular Weight: 376.84
• Mol File: 27060-91-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 142-147°
• Boiling Point: 601.9°Cat760mmHg
• Flash Point: 317.8°C
• Appearance: /
• Density: 1.2970 (estimate)
• Vapor Pressure: 2.44E-15mmHg at 25°C
• Refractive Index: 1.672
• PKA: 5.40(at 25℃)
• CAS DataBase Reference: Flutazolam(CAS DataBase Reference)
• NIST Chemistry Reference: Flutazolam(27060-91-9)
• EPA Substance Registry System: Flutazolam(27060-91-9)

Safety Data

• Hazardous Substances Data: 27060-91-9(Hazardous Substances Data)

Usage

Description

Flutazolam, marketed under the brand name COREMINAL, is a benzodiazepine anxiolytic that is closely related to mexazolam. It is characterized by its effectiveness in treating anxiety, stress, and depression, particularly in conditions such as hypersensitive colon syndrome, chronic gastritis, and gastric and duodenal ulcers.

Uses

Used in Pharmaceutical Industry:
Flutazolam is used as an anxiolytic agent for the treatment of anxiety, stress, and depression. It is particularly effective in managing these conditions in patients with hypersensitive colon syndrome, chronic gastritis, and gastric and duodenal ulcers.
Used in Gastroenterology:
Flutazolam is used as a therapeutic agent for the management of gastrointestinal disorders such as hypersensitive colon syndrome, chronic gastritis, and gastric and duodenal ulcers. Its anxiolytic properties help alleviate the stress and anxiety associated with these conditions, promoting overall well-being and improved quality of life for patients.

Originator

Hoffmanu-LaRoche (USA)

InChI:InChI=1/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2

Upstream product

• 105-36-2 ethyl bromoacetate 
• 24143-22-4 10-chloro-11b-(2-fluoro-phenyl)-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one 
• 540-51-2 2-bromoethanol 
• 101489-22-9 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-N-(2-hydroxy-ethyl)-2-(2-hydroxy-ethylamino)-acetamide 
• 102408-32-2 7-Chloro-5-(2-fluoro-phenyl)-1,4-bis-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium 

Downstream Products

• 35231-38-0 5-chloro-2'-fluoro-2-(2-hydroxyethyl)aminobenzophenone 
• 102408-32-2 7-Chloro-5-(2-fluoro-phenyl)-1,4-bis-(2-hydroxy-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium 
• 101489-20-7 N-(2-hydroxyethyl)-N-<2-(o-fluorobenzoyl)-4-chloro>phenyl-2-(2-hydroxyethyl)-aminoacetamide hydrochloride 

Relevant articles and documents

Kinetics and mechanism of the acid-base equilibrium of mexazolam and comparison with those of other commercial benzodiazepinooxazole drugs

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Intermediates for tricyclic benzodiazepines

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.